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中华胃食管反流病电子杂志

中华胃食管反流病电子杂志 ›› 2023, Vol. 10 ›› Issue (04) : 207 -211. doi: 10.3877/cma.j.issn.2095-8765.2023.04.009

综述

不同细胞因子与胃食管反流病的研究进展
王永康1, 买买提·依斯热依力2,†(), 克力木·阿不都热依木3   
  1. 1. 830001　乌鲁木齐，新疆维吾尔自治区人民医院自治区普外微创研究所;830001　乌鲁木齐，新疆维吾尔自治区胃食管反流病及减重代谢外科临床研究中心;830054　乌鲁木齐，新疆医科大学研究生学院
    2. 830001　乌鲁木齐，新疆维吾尔自治区人民医院自治区普外微创研究所;830001　乌鲁木齐，新疆维吾尔自治区胃食管反流病及减重代谢外科临床研究中心;830001　乌鲁木齐，新疆维吾尔自治区人民医院医学研究与转化中心
    3. 830001　乌鲁木齐，新疆维吾尔自治区人民医院自治区普外微创研究所;830001　乌鲁木齐，新疆维吾尔自治区胃食管反流病及减重代谢外科临床研究中心
  • 收稿日期:2023-03-12 出版日期:2023-11-15
  • 通信作者: 买买提·依斯热依力
  • 基金资助:
    新疆维吾尔自治区自然科学基金(2021D01C148)

Research progress on the relationship between different cytokines and gastroesophageal reflux disease

Yongkang Wang1, Yisireyili Maimaiti·2,†(), Abudureyimu Kelimu·3   

  1. 1. Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China;Clinical Research Center for Gastroesophageal Reflux Disease and Weight Loss Metabolic Surgery, Urumqi 830001, China;Xinjiang Medical University Graduate School of Medicine, Urumqi 830054, China
    2. Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China;Clinical Research Center for Gastroesophageal Reflux Disease and Weight Loss Metabolic Surgery, Urumqi 830001, China;Medical Research and Transformation Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
    3. Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China;Clinical Research Center for Gastroesophageal Reflux Disease and Weight Loss Metabolic Surgery, Urumqi 830001, China
  • Received:2023-03-12 Published:2023-11-15
  • Corresponding author: Yisireyili Maimaiti·
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引用本文：

王永康, 买买提·依斯热依力, 克力木·阿不都热依木. 不同细胞因子与胃食管反流病的研究进展[J]. 中华胃食管反流病电子杂志, 2023, 10(04): 207-211.

Yongkang Wang, Yisireyili Maimaiti·, Abudureyimu Kelimu·. Research progress on the relationship between different cytokines and gastroesophageal reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(04): 207-211.

胃食管反流病（GERD）被认为是全球最常见的慢性胃肠道疾病之一，GERD是成人和儿童的常见疾病。GERD的全球患病率很高，而且还在增加。非糜烂性反流病是GERD最常见的表型。烧心和反流被认为是典型症状，但胃食管反流可能表现为各种非典型和食管外表现。GERD的病理生理学是多因素的，不同的机制可能导致GERD症状，包括胃动力、抗反流屏障、反流特征、清除机制、黏膜完整性和肥胖等。在食管黏膜内，有各种各样的炎症因子、免疫介质、转录介质以及上皮分化和完整性的标志物，这些在食管炎中过度表达或表达不足，为具有诊断或预后潜力的生物标志物提供了许多候选者。清晰的炎症因子机制在GERD导致食管黏膜炎症治疗中有较高的临床应用价值。本文论述在GERD疾病中介导食管黏膜炎症损伤的一些重要和关键因素的研究进展。

关键词: 胃食管反流病, 食管炎, 炎症因子, 信号通路, 综述

Gastroesophageal reflux disease (GERD) is considered one of the most common chronic gastrointestinal diseases worldwide, and GERD is a common disease in adults and children. The global prevalence of GERD is high and increasing. Non erosive reflux disease is the most common phenotype of GERD. Heartburn and reflux are considered typical symptoms, but gastroesophageal reflux may manifest as various atypical and extraesophageal manifestations. The pathophysiology of GERD is multifactorial, and different mechanisms may lead to symptoms of GERD, including gastric motility, anti reflux barrier, reflux characteristics, clearance mechanisms, mucosal integrity, and obesity. In the esophageal mucosa, there are various inflammatory factors, immune mediators, transcriptional mediators, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in esophagitis, providing many candidates for biomarkers with diagnostic or prognostic potential. A clear mechanism of inflammatory factors has high clinical application value in the treatment of GERD induced esophageal mucosal inflammation. This article discusses the research progress of some important and key factors mediating esophageal mucosal inflammatory damage in GERD disease.

Key words: Gastroesophageal reflux disease, Esophagitis, Inflammatory factors, Signaling pathway, Review
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