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中华胃食管反流病电子杂志 ›› 2025, Vol. 12 ›› Issue (02) : 84 -88. doi: 10.3877/cma.j.issn.2095-8765.2025.02.006

综述

肠道菌群在溃疡性结肠炎与胃食管反流病共病机制中的作用
艾孜再·帕力哈提1, 黄晓玲2,()   
  1. 1830054 乌鲁木齐,新疆医科大学
    2830002 乌鲁木齐,新疆维吾尔自治区人民医院消化内科
  • 收稿日期:2025-04-10 出版日期:2025-05-15
  • 通信作者: 黄晓玲
  • 基金资助:
    新疆维吾尔自治区科技支疆项目计划(2024E02041)

The Role of Gut Microbiota in the Comorbidity Mechanisms of Ulcerative Colitis and Gastroesophageal Reflux Disease

Palihati Aizizai·1, Xiaoling Huang2,()   

  1. 1Xinjiang Medical University, Urumqi 830054, China
    2Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830002, China
  • Received:2025-04-10 Published:2025-05-15
  • Corresponding author: Xiaoling Huang
引用本文:

艾孜再·帕力哈提, 黄晓玲. 肠道菌群在溃疡性结肠炎与胃食管反流病共病机制中的作用[J/OL]. 中华胃食管反流病电子杂志, 2025, 12(02): 84-88.

Palihati Aizizai·, Xiaoling Huang. The Role of Gut Microbiota in the Comorbidity Mechanisms of Ulcerative Colitis and Gastroesophageal Reflux Disease[J/OL]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2025, 12(02): 84-88.

溃疡性结肠炎(UC)与胃食管反流病(GERD)是2种常见的消化系统疾病,虽然分别累及肠道和食管-胃区域,但近年来的研究表明,二者在病理生理机制、共用危险因素、药物影响及并发症等方面存在潜在的紧密联系。本文通过系统综述最新研究进展,重点探讨肠道菌群在UC与GERD相互作用中的关键纽带作用。研究发现,肠道屏障功能受损、神经-内分泌调节失衡以及肠道菌群介导的免疫炎症反应,可能是二者共同发病机制的核心环节。此外,饮食、精神心理因素以及药物使用等共用危险因素,进一步加剧了2种疾病的相互影响。本文旨在为临床诊疗提供理论依据,并呼吁未来研究深入探索肠道菌群在UC与GERD关联中的分子机制,以期为消化系统疾病的防治提供新思路。

Ulcerative colitis (UC) and gastroesophageal reflux disease (GERD) are two prevalent gastrointestinal disorders, affecting the intestinal tract and the esophagus-stomach region, respectively. However, recent studies have revealed potential intricate connections between them in terms of pathophysiological mechanisms, shared risk factors, pharmacological impacts, and complications. This review systematically synthesizes the latest research advancements, with a particular focus on the pivotal role of gut microbiota in the interplay between UC and GERD. Research findings suggest that impaired intestinal barrier function, neuroendocrine dysregulation, and gut microbiota-mediated immune-inflammatory responses may constitute the core mechanisms underlying the co-pathogenesis of these two conditions. Furthermore, shared risk factors such as diet, psychological factors, and medication use exacerbate their mutual influence. This review aims to provide a theoretical foundation for clinical diagnosis and treatment, and calls for future research to delve deeper into the molecular mechanisms of gut microbiota in the association between UC and GERD, thereby paving new avenues for the prevention and treatment of gastrointestinal diseases.

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