胃食管反流病（GERD）是一种常见的慢性上消化道疾病，其发病机制仍未明确。近年来，研究认为GERD的发病机制与食管下括约肌抗反流屏障的结构与功能障碍、反流物在食管的清除功能异常和食管黏膜屏障功能降低等因素密切相关。随着我国GERD发病率上升，对其认识也在不断深入。有研究证明精神心理因素与GERD存在密切关联，二者互为因果，相互影响，合并焦虑、抑郁的GERD患者生活质量较精神心理状态正常者低。本文将对焦虑、抑郁、睡眠障碍等影响因素与GERD的联系及其相关机制和治疗研究进展进行综述。

Gastroesophageal reflux disease (GERD) is a common chronic upper gastrointestinal disorder, and its pathogenesis remains unclear. Recent studies suggest that the pathogenesis of GERD is closely related to structural and functional disorders of the lower esophageal sphincter anti-reflux barrier, abnormal clearance of refluxate in the esophagus, and reduced esophageal mucosal barrier function. With the increasing incidence of GERD in China, our understanding of it is also deepening. Research has shown that there is a close association between mental and psychological factors and GERD, which are mutually causal and influence each other. GERD patients with anxiety and depression have a lower quality of life than those with normal mental and psychological states. This article will review the research progress on the relationship between influencing factors such as anxiety, depression, and sleep disorders and GERD, as well as the related mechanisms and treatments.