切换至 "中华医学电子期刊资源库"

中华胃食管反流病电子杂志 ›› 2018, Vol. 05 ›› Issue (02) : 65 -67. doi: 10.3877/cma.j.issn.1674-6899.2018.02.005

所属专题: 文献

论著

胃食管反流病对哮喘患者肺功能影响的研究
麦尔哈巴·哈力克1, 买买提·阿力木2, 杨晓红1,()   
  1. 1. 830000 乌鲁木齐,新疆维吾尔自治区人民医院呼吸与危重医学科
    2. 844000 喀什地区第一人民医院普内科
  • 收稿日期:2018-04-02 出版日期:2018-05-15
  • 通信作者: 杨晓红

Effect of gastroesophageal reflux disease on lung function in patients with asthma

Halike Maierhaba·1, Alimu Maimaiti·2, Xiaohong Yang1,()   

  1. 1. Respiratory and Critical Care Medicine, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
    2. Department of Internal Medicine, The first people′s Hospital of Kashi, Kashi 844000, China
  • Received:2018-04-02 Published:2018-05-15
  • Corresponding author: Xiaohong Yang
  • About author:
    Corresponding author: Yang Xiaohong, Email:
引用本文:

麦尔哈巴·哈力克, 买买提·阿力木, 杨晓红. 胃食管反流病对哮喘患者肺功能影响的研究[J]. 中华胃食管反流病电子杂志, 2018, 05(02): 65-67.

Halike Maierhaba·, Alimu Maimaiti·, Xiaohong Yang. Effect of gastroesophageal reflux disease on lung function in patients with asthma[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2018, 05(02): 65-67.

目的

探讨胃食管反流病对哮喘患者肺功能的影响。

方法

收集2015年5月至2017年8月新疆维吾尔自治区人民医院收治并确诊哮喘226例患者的临床资料,根据是否合并有胃食管反流病(GERD)患者分为GERD组102例和非GERD组124例,比较2组患者FEV1占预计值%、FVC占预计值%及FEV1 /FVC%等肺功能指标。

结果

GERD发生率45.1%(102/226),GERD组患者FEV1占预计值%、FVC占预计值%及FEV1/FVC%,明显低于非GERD组,差异有统计学意义(P<0.05)。

结论

哮喘与GERD密切相关,GERD对哮喘患者肺功能影响大,GERD与哮喘是因果还是伴随关系仍需进一步研究。

Objective

To investigate the effect of gastroesophageal reflux disease on lung function in patients with asthma.

Methods

There were admitted to Department of respiration and diagnosed asthma patients 226 cases who from May 2015 to August 2017 in the people′s hospital of Xinjiang Uygur Autonomous Region, according to whether complicated with GERD were divided into GERD group and non GERD group, compared two groups of patients with FEV1%, FVC% and FEV1/FVC% pulmonary function index.

Results

The incidence of GERD was 45.1%(102/226), GERD group of FEV1 %, FVC% and FEV1/FVC% were significantly lower than non GERD group, and the difference was statistically significant(P<0.05).

Conclusion

GERD is closely related with asthma, GERD has great influence on the pulmonary function of asthma patients, GERD and asthma is causal or accompanying relationship still need further study.

表1 胃食管反流病与哮喘2组食管压力学指标比较(±s)
1
Wang ZG, Wu JM, Liu JJ, et al.Respiratory Distress Resulting from Gastroesophageal Reflux Is not Asthma, but Laryngotracheal Irritation, Spasm, even Suffocation[J]. Chin Med Sci J, 2009, 24(2):130-132.
2
Vakil N, van Zanten SV, Kahrilas P, et al.The Montreal definition and classification of gastroesophageal reflux disease:a global evidence-based consensus papaer[J]. Z Gastroenterol, 2007, 45(11):1125-1140.
3
Houghton LA, Lee AS, Badri H, et al.Respiratory disease and the oesophagus:reflux, reflexes and microaspiration[J]. Nat Rev Gastroenterol Hepatol, 2016, 13(8):445-460.
4
Bateman ED, Hurd SS, Barnes PJ, et al.Global strategy for asthma management and prevention:GINA executive summary[J]. Eur Respiratory, 2008, 31(1):143-178.
5
华雯, 黄华琼, 沈华浩. 《支气管哮喘防治指南(2016年版)》解读[J]. 浙江大学学报(医学版), 2016, 45(5):447-452.
6
Havemann BD, Henderson CA, El-Serag HB, et al.The association between gastro-oesophageal reflux disease and asthma:a systematic review.[J]. Gut, 2007, 56(12):1654-1664.
7
Min YW, Woo LS, Haeng LJ, et al.Prevalence of extraesophageal symptoms in patients with gastroesophageal reflux disease:a multicenter questionnaire-based study in Korea[J]. J Neurogastroenterol Motil, 2014, 20(1):87-93.
8
中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2016年版)[J]. 中华结核和呼吸杂志, 2016, 39(9):675-697.
9
陈旻湖, 侯晓华, 肖英莲, 等. 2014年中国胃食管反流病专家共识意见[J]. 胃肠病学, 2015, (3):155-168.
10
Onyekwere CA, Adeyeye OO, Ogbera AO, et al.Prevalence of gastroesophageal reflux disease among patients with bronchial asthma[J]. Trop Gastroenterol, 2010, 31(3):195-198.
11
Ozcan C, Erkoçoğlu M, Civelek E, et al.The relationship between gastro-oesophageal reflux disease and asthma during childhood[J]. Allergologia et Immunopathologia, 2014, 42(2):109-114.
12
Tsuboi K, Hoshino M, Sundaram A, et al.Role of the lower esophageal sphincter on esophageal cid exposure a review of over 2000 patients[J]. Trop Gastroenterol, 2012, 33(2):107-111.
13
Houghton LA, Lee AS, Badri H, et al.Respiratory disease and the oesophagus:reflux, reflexes and microaspiration [J]. Nat Rev Gastroenterol Hepatol, 2016, 13(8):445-460.
14
Hong CM, Galvagno SM Jr.Patients with chronic pulmonary disease [J]. Med Clin North Am, 2013, 97(6):1095-1107.
15
贾平, 朱海杭. 缺氧与胃食管反流病关系的研究进展[J]. 国际消化病杂志, 2016, 36(1):34-36.
16
Stein MR.Possible mechanisms of influence of esophageal acid on airway hyperrespons on siveness [J]. Am J Med, 2003, 115(S3A):55S-59S.
17
Gam aletsou MN, Denning DW.Gastroesophageal reflux disease and pulmonary diseases associated with aspergillosis:is there a connection?[J]. Mycopathologia, 2017, 182(11-12):1125-1129.
18
朱莎, 李芳. 胃食管反流源性哮喘发病机制的研究现状[J]. 大连医科大学学报, 2013, 35(6):611-613.
[1] 陈腊青, 林佳佳, 毛洪刚, 童冠海, 汪梦娜, 夏红波, 刘卓, 徐海霞, 赵玉华, 张传领. 血清细胞因子及呼出气一氧化氮在哮喘-慢性阻塞性肺疾病重叠综合征中的临床意义[J]. 中华危重症医学杂志(电子版), 2023, 16(04): 316-320.
[2] 杨皓媛, 龚杰, 邹青伟, 阮航. 哮喘孕妇的母婴不良妊娠结局研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 522-529.
[3] 娄丽丽, 刘瀚旻. 儿童哮喘易感基因及表观遗传学研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 249-255.
[4] 李世红, 侯康. 腹腔镜食管裂孔疝补片修补术联合胃底折叠术(Nissen)[J]. 中华普通外科学文献(电子版), 2023, 17(05): 365-365.
[5] 王鸿彬, 何晓, 吴菁宙. 腹腔镜近端胃切除术中背驮式间置空肠单通道重建术在AEG手术的安全性及抗反流效果研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 526-529.
[6] 赵国栋, 施喆, 孙树刚, 薛亮, 王晓辉, 杨勇. 两种消化道重建方案的腹腔镜近端胃切除术后患者胃内压变化的对比研究[J]. 中华普外科手术学杂志(电子版), 2023, 17(03): 292-295.
[7] 贾卓奇, 周维茹, 张勇, 张广健, 付军科. 达·芬奇机器人与腹腔镜食管裂孔疝修补术的对比研究[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(04): 410-414.
[8] 王刚, 单伟根, 刘娟, 李长庆, 王新民. 常规治疗联合阿托伐他丁钙片对支气管扩张症临床分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 538-540.
[9] 张荷连, 刘禹, 李丹妮, 彭茹, 杨彩蝶, 窦恒, 吴红梅. 心理障碍对重度哮喘患者的疾病控制及生活工作质量的影响[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 589-591.
[10] 刘佳铭, 孙晓容, 文健, 何晓丽, 任茂玲. 有氧运动对成人哮喘肺功能、生活质量以及哮喘控制影响的Meta分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 592-595.
[11] 谭玲芳, 周克兵. 基于生物信息学整合鉴定与支气管哮喘相关的潜在诊断生物标志物[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 329-334.
[12] 路东明, 陈建华, 艾月琴. 布地格福吸入气雾剂治疗支气管哮喘的临床分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 361-363.
[13] 刘康凯, 姚光辉. 补肺纳肾汤对COPD稳定期患者肺功能及外周血Treg、Th17细胞比率的影响[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 376-378.
[14] 孙臣忠, 韩碧芸, 陈虹, 陈英, 周军. 慢性阻塞性肺疾病免疫球蛋白亚型与肺功能相关性分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(03): 403-405.
[15] 闫文貌, 孙海涛, 白日星. 胃袖状切除相关术式中应重视胃窦部解剖与生理功能[J]. 中华肥胖与代谢病电子杂志, 2023, 09(03): 161-164.
阅读次数
全文


摘要