切换至 "中华医学电子期刊资源库"

中华胃食管反流病电子杂志 ›› 2018, Vol. 05 ›› Issue (02) : 65 -67. doi: 10.3877/cma.j.issn.1674-6899.2018.02.005

所属专题: 文献

论著

胃食管反流病对哮喘患者肺功能影响的研究
麦尔哈巴·哈力克1, 买买提·阿力木2, 杨晓红1,()   
  1. 1. 830000 乌鲁木齐,新疆维吾尔自治区人民医院呼吸与危重医学科
    2. 844000 喀什地区第一人民医院普内科
  • 收稿日期:2018-04-02 出版日期:2018-05-15
  • 通信作者: 杨晓红

Effect of gastroesophageal reflux disease on lung function in patients with asthma

Halike Maierhaba·1, Alimu Maimaiti·2, Xiaohong Yang1,()   

  1. 1. Respiratory and Critical Care Medicine, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
    2. Department of Internal Medicine, The first people′s Hospital of Kashi, Kashi 844000, China
  • Received:2018-04-02 Published:2018-05-15
  • Corresponding author: Xiaohong Yang
  • About author:
    Corresponding author: Yang Xiaohong, Email:
引用本文:

麦尔哈巴·哈力克, 买买提·阿力木, 杨晓红. 胃食管反流病对哮喘患者肺功能影响的研究[J/OL]. 中华胃食管反流病电子杂志, 2018, 05(02): 65-67.

Halike Maierhaba·, Alimu Maimaiti·, Xiaohong Yang. Effect of gastroesophageal reflux disease on lung function in patients with asthma[J/OL]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2018, 05(02): 65-67.

目的

探讨胃食管反流病对哮喘患者肺功能的影响。

方法

收集2015年5月至2017年8月新疆维吾尔自治区人民医院收治并确诊哮喘226例患者的临床资料,根据是否合并有胃食管反流病(GERD)患者分为GERD组102例和非GERD组124例,比较2组患者FEV1占预计值%、FVC占预计值%及FEV1 /FVC%等肺功能指标。

结果

GERD发生率45.1%(102/226),GERD组患者FEV1占预计值%、FVC占预计值%及FEV1/FVC%,明显低于非GERD组,差异有统计学意义(P<0.05)。

结论

哮喘与GERD密切相关,GERD对哮喘患者肺功能影响大,GERD与哮喘是因果还是伴随关系仍需进一步研究。

Objective

To investigate the effect of gastroesophageal reflux disease on lung function in patients with asthma.

Methods

There were admitted to Department of respiration and diagnosed asthma patients 226 cases who from May 2015 to August 2017 in the people′s hospital of Xinjiang Uygur Autonomous Region, according to whether complicated with GERD were divided into GERD group and non GERD group, compared two groups of patients with FEV1%, FVC% and FEV1/FVC% pulmonary function index.

Results

The incidence of GERD was 45.1%(102/226), GERD group of FEV1 %, FVC% and FEV1/FVC% were significantly lower than non GERD group, and the difference was statistically significant(P<0.05).

Conclusion

GERD is closely related with asthma, GERD has great influence on the pulmonary function of asthma patients, GERD and asthma is causal or accompanying relationship still need further study.

表1 胃食管反流病与哮喘2组食管压力学指标比较(±s)
1
Wang ZG, Wu JM, Liu JJ, et al.Respiratory Distress Resulting from Gastroesophageal Reflux Is not Asthma, but Laryngotracheal Irritation, Spasm, even Suffocation[J]. Chin Med Sci J, 2009, 24(2):130-132.
2
Vakil N, van Zanten SV, Kahrilas P, et al.The Montreal definition and classification of gastroesophageal reflux disease:a global evidence-based consensus papaer[J]. Z Gastroenterol, 2007, 45(11):1125-1140.
3
Houghton LA, Lee AS, Badri H, et al.Respiratory disease and the oesophagus:reflux, reflexes and microaspiration[J]. Nat Rev Gastroenterol Hepatol, 2016, 13(8):445-460.
4
Bateman ED, Hurd SS, Barnes PJ, et al.Global strategy for asthma management and prevention:GINA executive summary[J]. Eur Respiratory, 2008, 31(1):143-178.
5
华雯, 黄华琼, 沈华浩. 《支气管哮喘防治指南(2016年版)》解读[J]. 浙江大学学报(医学版), 2016, 45(5):447-452.
6
Havemann BD, Henderson CA, El-Serag HB, et al.The association between gastro-oesophageal reflux disease and asthma:a systematic review.[J]. Gut, 2007, 56(12):1654-1664.
7
Min YW, Woo LS, Haeng LJ, et al.Prevalence of extraesophageal symptoms in patients with gastroesophageal reflux disease:a multicenter questionnaire-based study in Korea[J]. J Neurogastroenterol Motil, 2014, 20(1):87-93.
8
中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2016年版)[J]. 中华结核和呼吸杂志, 2016, 39(9):675-697.
9
陈旻湖, 侯晓华, 肖英莲, 等. 2014年中国胃食管反流病专家共识意见[J]. 胃肠病学, 2015, (3):155-168.
10
Onyekwere CA, Adeyeye OO, Ogbera AO, et al.Prevalence of gastroesophageal reflux disease among patients with bronchial asthma[J]. Trop Gastroenterol, 2010, 31(3):195-198.
11
Ozcan C, Erkoçoğlu M, Civelek E, et al.The relationship between gastro-oesophageal reflux disease and asthma during childhood[J]. Allergologia et Immunopathologia, 2014, 42(2):109-114.
12
Tsuboi K, Hoshino M, Sundaram A, et al.Role of the lower esophageal sphincter on esophageal cid exposure a review of over 2000 patients[J]. Trop Gastroenterol, 2012, 33(2):107-111.
13
Houghton LA, Lee AS, Badri H, et al.Respiratory disease and the oesophagus:reflux, reflexes and microaspiration [J]. Nat Rev Gastroenterol Hepatol, 2016, 13(8):445-460.
14
Hong CM, Galvagno SM Jr.Patients with chronic pulmonary disease [J]. Med Clin North Am, 2013, 97(6):1095-1107.
15
贾平, 朱海杭. 缺氧与胃食管反流病关系的研究进展[J]. 国际消化病杂志, 2016, 36(1):34-36.
16
Stein MR.Possible mechanisms of influence of esophageal acid on airway hyperrespons on siveness [J]. Am J Med, 2003, 115(S3A):55S-59S.
17
Gam aletsou MN, Denning DW.Gastroesophageal reflux disease and pulmonary diseases associated with aspergillosis:is there a connection?[J]. Mycopathologia, 2017, 182(11-12):1125-1129.
18
朱莎, 李芳. 胃食管反流源性哮喘发病机制的研究现状[J]. 大连医科大学学报, 2013, 35(6):611-613.
[1] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[2] 白浪, 张雪玉, 白铁成, 贺爱军. 腹腔镜近端胃切除术中圆锥形重叠吻合成形术对Siewert Ⅱ型AEG患者胃食管反流、营养状态的影响研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 679-682.
[3] 李海云, 赵敏娴, 申英末, 杨慧琪. 胃底折叠术预防食管裂孔疝术后并发症的研究进展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 485-490.
[4] 玉素江·图荪托合提, 韩琦, 麦麦提艾力·麦麦提明, 黄旭东, 王浩, 克力木·阿不都热依木, 艾克拜尔·艾力. 腹腔镜袖状胃切除或联合食管裂孔疝修补术对肥胖症合并胃食管反流病的中期疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 501-506.
[5] 任传富, 杨志, 徐恩, 何梓芸, 罗板鑫, 陈新, 夏雪峰. 腹腔镜疝修补术联合胃底折叠术治疗食管裂孔疝合并胃食管反流病40 例临床分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 507-511.
[6] 杜晨阳, 王勇, 段鑫, 柯文杰, 石念, 武英翔, 罗文. 腹腔镜下食管裂孔疝修补术后吞咽困难的危险因素分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 523-527.
[7] 沈琪乐, 赵勤华, 宫素岗, 刘锦铭, 王岚, 邱宏玲. COPD 稳定期患者血清CC16 蛋白表达与肺功能、肺气肿表型的关系分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 690-695.
[8] 杨莎莎, 张毛为, 孙宜田, 刘亚南, 位娟, 魏建, 陈碧. 结缔组织疾病相关间质性肺病并发小气道功能障碍临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 738-743.
[9] 郭璟琪, 魏明言, 刘芳, 李冬凌, 关金平, 李立华. 乙酰半胱氨酸治疗慢性阻塞性肺疾病急性加重期的疗效分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 768-772.
[10] 刘雯, 赵明栋, 夏伟, 潘以雄. 不同剂量比阿培南治疗重症肺炎的疗效分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 789-792.
[11] 张璇, 高杨, 房雅君, 姚艳玲. 保护性机械通气在肺癌胸腔镜肺段切除术中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 563-567.
[12] 陈冬丽, 邓迎丽, 毕婧. α-干扰素治疗急性呼吸道病毒感染对Th1/Th2平衡及肺功能的影响[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 590-594.
[13] 胡志伟, 吴继敏, 邓昌荣, 战秀岚, 纪涛, 王峰, 田书瑞, 陈冬, 张玉, 刘健男, 宋庆. 抗反流黏膜套扎治疗顽固性胃食管反流病[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(04): 227-233.
[14] 唐小久, 胡曼, 许必君, 肖亚. 肥胖合并胃食管反流病患者严重程度与其焦虑抑郁及营养状态的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 360-364.
[15] 闫维, 张二明, 张克, 安欣华, 向平超. 北京市石景山区40岁及以上居民早期慢性阻塞性肺疾病异质性及影响因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 533-540.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?