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中华胃食管反流病电子杂志 ›› 2018, Vol. 05 ›› Issue (03) : 135 -139. doi: 10.3877/cma.j.issn.2095-8765.2018.03.010

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综述

GERD食管上皮组织紧密连接蛋白和氧化应激在发病中的研究进展
曹正一1, 买买提·依斯热依力2, 克力木·阿不都热依木2,()   
  1. 1. 830001 乌鲁木齐,新疆医科大学研究生院
    2. 830001 乌鲁木齐,新疆维吾尔自治区人民医院普外微创研究所;830001 乌鲁木齐,新疆维吾尔自治区人民医院微创、疝和腹壁外科
  • 收稿日期:2018-03-20 出版日期:2018-08-15
  • 通信作者: 克力木·阿不都热依木

Role of tight junction proteins and oxidative stress in the pathogenesis of GERD

Zhengyi Cao1, Yisireyili Maimaiti·2, Abudureyimu Kelimu·2,()   

  1. 1. Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, 830001, China
    2. Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China
  • Received:2018-03-20 Published:2018-08-15
  • Corresponding author: Abudureyimu Kelimu·
  • About author:
    Corresponding author: Kelimu·Abudureyimu, Email:
引用本文:

曹正一, 买买提·依斯热依力, 克力木·阿不都热依木. GERD食管上皮组织紧密连接蛋白和氧化应激在发病中的研究进展[J]. 中华胃食管反流病电子杂志, 2018, 05(03): 135-139.

Zhengyi Cao, Yisireyili Maimaiti·, Abudureyimu Kelimu·. Role of tight junction proteins and oxidative stress in the pathogenesis of GERD[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2018, 05(03): 135-139.

胃食管反流病(GERD)是一种全球性疾病,国内外流行病学调查证明该病患病率正在增加,并且严重影响患者生活。目前研究显示该病的发病机制极其复杂,故对其研究也是日益深入。近年,有学者用透射电镜或电子光镜发现GERD患者食管下段上皮细胞存在细胞间隙增宽(DIS)这形态学改变,而这可能是食管上皮细胞损伤的一个早期、敏感的形态学指标,因其为食管微观结构的宏观改变,故激发了研究者的研究兴趣,欣起一片该研究方向的热潮。另一方面,氧化应激(OS)也被相关实验研究表明参与食管黏膜的损伤过程。近期国内外的研究进一步提出OS与GERD的发生发展有较密切的关系,而OS过量产生导致食管氧化/抗氧化防御系统受损,进而引起食管上皮存在的紧密连接蛋白结构和功能的异常,结果导致食管上皮的DIS可能是GERD发病机制之一。本文将对以上方面研究现状作一综述。

Gastroesophageal reflux disease (GERD) is a global diseases, the epidemiological studies from both domestic and oversea countries have shown that incidences rate of GERD significantly increased, and severely effects of patients quality of life. Now studies revealed that the pathogenesis of GERD greatly complicated, hence the research studies now gradually paying attention to its mechanism. Recent years, some investigators by using the transmission electron microscopy (TEM) or electronic light microscopy have found that there some morphological changes were exist in the lower esophageal epithelial cells of GERD patients, and speculate that change may be an early and sensitive morphological index of esophageal epithelial cell (microstructures of the esophagus) damage. Therefore, this finding were provided a potential ideas to researchers and inspired them a lot. Furthermore, relative experimental studies reveled that oxidative stress (OS) positively attained to the pathogenesis of esophageal mucosa damage. Just recently, the studies from both domestic and overseas further shown that OS significantly related to the occurrence and development of GERD. The over production of OS impairs the balances of oxidative/anti-oxidative defence system of esophagus, then leads to the abnormal change of esophageal microsturucre and function of tight junction (TJ) proteins, in result induce dilated intercellular space (DIS) of esophageal epithelial cells might be one of the potential mechanism of GERD. In this paper, the research status of the above aspects will further reviewed.

[1]
王志,张成,王俭,等. GerdQ量表在胃食管反流病诊断中的应用[J/CD].中华胃食管反流病电子杂志, 2014, 1(1):36-38.
[2]
杜智,张成,克力木·阿不都热依木,等.高分辨率食管测压与食管24h pH监测在胃食管反流病中的应用价值[J/CD].中华胃食管反流病电子杂志, 2015, 2(3):147-151.
[3]
瞿国强.胃食管反流病的流行病学研究现状[J].中国临床保健杂志, 2011, 14(6):660-663.
[4]
韩梦婷,李治建,等.胃食管反流病的研究进展[J].中国当代医药, 2017, 24(25):13-16.
[5]
Saegusa. Y, Takeda H, Muto S, et al, Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling [J]. Biol Pharm Bull, 2011, 34(5):704-711.
[6]
Farré R, De Vos R, Geboes K, et al, Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces[J]. Gut, 2007, 56(9):1191.
[7]
Knowles CH, Aziz O. Visceral hypersensitivity in non-erosive reflux disease [J]. Gut, 2008, 57(5):674.
[8]
谭佳成,叶必星,林琳,等,胃食管反流病相关的细胞间隙增宽和紧密连接蛋白[J].胃肠病学, 2013. 18(10):636-638.
[9]
Weijenborg PW, Smout AJ, Verseijden C, et al. Hypersensitivity to acid is associated with impaired esophageal mucosal integrity in patients with gastroesophageal reflux disease with and without esophagitis [J]. Am J Physiol Gastrointest Liver Physiol, 2014, 307(3):G323-329.
[10]
刘荣泉,那吉,陶家丽,等.贲门松弛与胃食管反流病患者的食管下段DIS改变[J].胃肠病学和肝病学杂志, 2016, 25(1):62-65.
[11]
Woodland P, Al-Zinaty M, Yazaki E, et al , In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease [J]. Gut, 2013,62(9):1256.
[12]
Souza RF, Huo X, Mittal V, et al , Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury [J]. Gastroenterology, 2009, 137(5):1776-1784.
[13]
Calabrese C, Fabbri A, Bortolotti M, et al , Dilated intercellular spaces as a marker of oesophageal damage: comparative results ingastro-oesophageal reflux disease with or without bile reflux [J]. Aliment Pharmacol Ther,2003,18(5):525-532.
[14]
徐姝燕,富建华.紧密连接相关蛋白Occludin的研究进展[J].国际儿科学杂志, 2012, 39(5):451-454.
[15]
陈意,李方方,张勇,等.肠黏膜上皮组织紧密连接的生物学功能和作用机理[J].动物营养学报, 2017, 29(9):3068-3074.
[16]
Van Itallie CM, Anderson JM. Architecture of tight junctions and principles of molecular composition [J]. Semin Cell Dev Biol, 2014, 36:157-165.
[17]
Jovov B, Que J, Tobey NA, et al. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease[J]. Am J Gastroenterol, 2011, 106(6):1039-1047.
[18]
雷军,夏祥国.紧密连接蛋白claudin的研究进展[J].西南医科大学学报, 2009, 32(6):655-657.
[19]
闫洪领,王季猛.胞质紧密粘连蛋白1的研究现状[J].医学综述, 2008, 14(17):2589-2591.
[20]
刘贝妮,姚树坤.食管黏膜屏障功能及其检测方法研究进展[J].胃肠病学和肝病学杂志, 2014, 23(12):1373-1375.
[21]
周童,仵敏娟.连接黏附分子A的研究进展[J].生命科学, 2013(9):865-870.
[22]
Yoshida N. Inflammation and oxidative stress in gastroesophageal reflux disease[J]. J Clin Biochem Nutr, 2007,40:13-23.
[23]
Mönkemüller K, Wex T, Kuester D, et al. Interleukin-1Beta and Interleukin-8 Expression Correlate with the Histomorphological Changes in Esophageal Mucosa of Patients with Erosive and Non- Erosive Reflux Disease [J]. Digestion, 2009. 79(3):186-195.
[24]
Oh TY, Lee JS, Ahn BO, et al. Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment [J]. Free Radical Bio Med, 2001, 30(8):905-915.
[25]
Chen H, Hu Y, Fang Y, et al. Nrf2 deficiency impairs the barrier function of mouse esophageal epithelium [J]. Gut, 2014,63(5):711-719.
[26]
Wakabayashi N, Itoh K, Wakabayashi J, et al, Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation[J]. Nature Genetics,2003, 35(3):238-245.
[27]
Fang Y, Chen H, Hu Y, et al. Gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mic[J]. Am J Physiol-Gastr L, 2013. 305(1):pG58.
[28]
Li FY, Li Y. Interleukin-6, desmosome and tight junction protein expression levels in reflux esophagitis-affected mucosa[J]. World J Gastroenterol, 2009, 15(29):3621-3630.
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