探讨肠型化生巴雷特食管（BE）的相关危险因素。

收集2017年1月至2020年1月在新疆维吾尔自治区人民医院诊治的55例肠型BE和性别、居住情况匹配的110例非肠型BE患者的临床资料，对两组患者基本状况、生活习惯以及临床病理参数进行回顾性分析，对比分析两组患者临床资料差异性，利用Logistic回归分析筛选肠型BE发生、发展相关的危险因素。

本院肠型BE患者检出率为3.7%（55例），其中男性占56.4%（31例），女性占43.6%（24例），平均年龄为57.73±6.54岁。肠型和非肠型BE患者在年龄、体重指数（BMI）、是否伴有胃食管反流病（GERD）症状和食管裂空疝、是否有食管癌家族史、血清幽门螺旋菌（HP）感染状态以及按化生的柱状上皮长度分型差异有统计学意义（P＜0.05）；在吸烟、饮酒、咖啡因摄入、饮茶习惯、结肠腺瘤诊断史及BE和结直肠癌家族史等上均无统计学意义（P＞0.05）。年龄≥50岁（P=0.031，OR=3.027，95%CI：1.107-8.278）、BMI＞25 kg/m²（P=0.029，OR=2.300，95%CI：1.089-4.856）和食管癌家族史（P=0.020，OR=2.420，95%CI：1.152-5.084）是肠型BE的危险因素。

年龄≥50岁、高BMI以及食管癌家族史是BE，尤其是肠型BE的危险因素，应加强具有上述危险因素的高危人群的健康宣传和管理，注重消化系统内镜监测，防止其发展为恶性肿瘤。

To explore the risk factors of intestinal metaplasia Barrett's esophagus (BE).

The clinical data of 55 patients with intestinal metaplasia type BE and 110 patients with non-intestinal metaplasia type BE who were matched by gender and living conditions and treated in our hospital from January 2017 to January 2020 were collected. The basic condition, lifestyle intervention and clinical pathological parameters of the two groups were analyzed retrospectively, meanwhile the differences of clinical data between the two groups were compared. Logistic regression analysis was used to screen the risk factors related to the occurrence and development of intestinal metaplasia type BE.

The detection rate of intestinal metaplasia type BE in our hospital was 3.7% (55 cases), of which 56.4% (31 cases) were males and 43.6% (24 cases) were females. The average age was 57.73±6.54 years old. There were significant differences in age, body mass index (BMI), gastroesophageal reflux disease (GERD) symptoms, esophageal hiatus hernia, family history of esophageal cancer, serum helicobacter pylori(HP) infection status and metaplastic columnar epithelium length between intestinal metaplasia type and non-intestinal metaplasia type of BE, however, there was no statistical significance in smoking, alcohol consumption, caffeine intake, tea drinking habit, diagnostic history of colonic adenoma, family history of BE and colorectal cancer. Age ≥50 years (P=0.031, OR=3.027, 95% CI: 1.107-8.278), BMI ＞25 kg/m² (P=0.029, OR=2.300, 95% CI: 1.089-4.856), and family history of esophageal cancer (P=0.020, OR=2.420, 95% CI: 1.152-5.084) were risk factors for intestinal metaplasia type of BE.

Age ≥50 years old, high BMI and family history of esophageal cancer are the risk factors of BE, especially intestinal BE. We should strengthen the health publicity and management of the high-risk population with the above risk factors, pay attention to endoscopic monitoring of the digestive system, and prevent it from developing into malignant tumor.