探讨内镜下不同亚型胃食管反流病与幽门螺旋杆菌感染之间的关系。

收集2021年3月至2022年6月因“反酸、烧心”就诊于兰州大学第一医院行胃镜检查诊断为胃食管反流病的成年患者325例为观察组，同时选取同期无症状健康体检者285名作为对照组，比较2组患者幽门螺旋杆菌感染情况，并分析不同亚型胃食管反流病与幽门螺旋杆菌感染的相关性。

2组患者间年龄、性别、体质量指数比较，差异均无统计学意义（P>0.05）。观察组与对照组幽门螺旋杆菌感染率为别为52.6%和56.1%，差异无统计学意义（P>0.05）；但患有反流性食管炎的患者幽门螺旋杆菌感染率为41.9%，与对照组相比差异有统计学意义（P<0.05）。观察组患者胃镜表现为：非糜烂性食管炎122例，A级107例，B级67例，C级23例，D级3例，Barrett食管5例。其Hp感染率为别为71.3%、52.3%、35.4%、17.4%、0/3和1/5，各组间差异有统计学意义（P<0.05）。

在反流性食管炎患者中，幽门螺旋杆菌感染率随着疾病等级增高而降低，幽门螺旋杆菌感染可能具有延缓病情进展作用，而与其感染程度无明显相关性。

To investigate the relationship between different endoscopic subtypes of gastroesophageal reflux disease and H. pylori infection.

A total of 325 adult patients who were diagnosed as gastroesophageal reflux disease due to acid reflux and heartburn in our hospital from March 2021 to June 2022 and underwent gastroscopy were selected as the observation group, while 285 asymptomatic healthy persons who underwent gastroscopy during the same period were selected as the control group, and helicobacter pylori infection was compared between the two groups. Meanwhile,the correlation between different subtypes of gastroesophageal reflux disease and helicobacter pylori infection was analyzed.

There were no significant differences in age, gender and body mass index between two groups. The Hp infection rate between the observation group and the control group was 52.6% and 56.1%, and there was no significant difference between the two groups (P>0.05). However, the Hp infection rate of the patients with reflux esophagitis was 41.9%, and the difference was statistically significant (P<0.05). In the observation group, there were 122 cases of non-erosive esophagitis, 107 cases of grade A, 67 cases of grade B, 23 cases of grade C, 3 cases of grade D and 5 cases f Barrett's oesophagus. The infection rates of Hp were 71.3%、52.3%、35.4%、17.4%、0/3和1/5, and there were significant differences among all groups (P<0.05).

In patients with reflux esophagitis, the infection rate of Hp decreases with the increase of disease grade, which may delay the progression of the disease.However, there was no obvious correlation with its degree of infection.