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中华胃食管反流病电子杂志

中华胃食管反流病电子杂志 ›› 2023, Vol. 10 ›› Issue (01) : 1 -5. doi: 10.3877/cma.j.issn.2095-8765.2023.01.001

论著

幽门螺旋杆菌感染与不同亚型胃食管反流病的相关性
张晓贝, 王伟刚, 李晓龙, 易风俊, 俞永江†()   
  1. 730000　兰州大学第一医院胃肠疝与腹壁外科
    730000　兰州大学第一临床医学院
    731600　临夏，甘肃康盛惠民医院普外科
    730000　兰州大学第一医院胃肠疝与腹壁外科;730000　兰州大学第一临床医学院
  • 收稿日期:2022-12-20 出版日期:2023-02-15
  • 通信作者: 俞永江
  • 基金资助:
    甘肃省自然科学基金(21JR1RA075)

Correlation of H. pylori infection and different subtypes of gastroesophageal reflux disease

Xiaobei Zhang, Weigang Wang, Xiaolong Li, Fengjun Yi, Yongjiang Yu†()   

  1. Department of Gastrointestinal,Hernia and Abdomal Wall surgery, First Hospital of Lanzhou University, Lanzhou 730000, China
    The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
    General Surgery Department of Gansu Kangsheng Huimin Hospital, Lanzhou 730000, China
    Department of Gastrointestinal,Hernia and Abdomal Wall surgery, First Hospital of Lanzhou University, Lanzhou 730000, China;The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
  • Received:2022-12-20 Published:2023-02-15
  • Corresponding author: Yongjiang Yu
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引用本文：

张晓贝, 王伟刚, 李晓龙, 易风俊, 俞永江. 幽门螺旋杆菌感染与不同亚型胃食管反流病的相关性[J]. 中华胃食管反流病电子杂志, 2023, 10(01): 1-5.

Xiaobei Zhang, Weigang Wang, Xiaolong Li, Fengjun Yi, Yongjiang Yu. Correlation of H. pylori infection and different subtypes of gastroesophageal reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(01): 1-5.

目的

探讨内镜下不同亚型胃食管反流病与幽门螺旋杆菌感染之间的关系。

方法

收集2021年3月至2022年6月因“反酸、烧心”就诊于兰州大学第一医院行胃镜检查诊断为胃食管反流病的成年患者325例为观察组，同时选取同期无症状健康体检者285名作为对照组，比较2组患者幽门螺旋杆菌感染情况，并分析不同亚型胃食管反流病与幽门螺旋杆菌感染的相关性。

结果

2组患者间年龄、性别、体质量指数比较，差异均无统计学意义（P>0.05）。观察组与对照组幽门螺旋杆菌感染率为别为52.6%和56.1%，差异无统计学意义（P>0.05）；但患有反流性食管炎的患者幽门螺旋杆菌感染率为41.9%，与对照组相比差异有统计学意义（P<0.05）。观察组患者胃镜表现为：非糜烂性食管炎122例，A级107例，B级67例，C级23例，D级3例，Barrett食管5例。其Hp感染率为别为71.3%、52.3%、35.4%、17.4%、0/3和1/5，各组间差异有统计学意义（P<0.05）。

结论

在反流性食管炎患者中，幽门螺旋杆菌感染率随着疾病等级增高而降低，幽门螺旋杆菌感染可能具有延缓病情进展作用，而与其感染程度无明显相关性。

关键词: 胃食管反流病, 幽门螺旋杆菌, 反流性食管炎, 相关性
Objective

To investigate the relationship between different endoscopic subtypes of gastroesophageal reflux disease and H. pylori infection.

Methods

A total of 325 adult patients who were diagnosed as gastroesophageal reflux disease due to acid reflux and heartburn in our hospital from March 2021 to June 2022 and underwent gastroscopy were selected as the observation group, while 285 asymptomatic healthy persons who underwent gastroscopy during the same period were selected as the control group, and helicobacter pylori infection was compared between the two groups. Meanwhile,the correlation between different subtypes of gastroesophageal reflux disease and helicobacter pylori infection was analyzed.

Results

There were no significant differences in age, gender and body mass index between two groups. The Hp infection rate between the observation group and the control group was 52.6% and 56.1%, and there was no significant difference between the two groups (P>0.05). However, the Hp infection rate of the patients with reflux esophagitis was 41.9%, and the difference was statistically significant (P<0.05). In the observation group, there were 122 cases of non-erosive esophagitis, 107 cases of grade A, 67 cases of grade B, 23 cases of grade C, 3 cases of grade D and 5 cases f Barrett's oesophagus. The infection rates of Hp were 71.3%、52.3%、35.4%、17.4%、0/3和1/5, and there were significant differences among all groups (P<0.05).

Conclusion

In patients with reflux esophagitis, the infection rate of Hp decreases with the increase of disease grade, which may delay the progression of the disease.However, there was no obvious correlation with its degree of infection.

Key words: Gastroesophageal reflux disease, Helicobacter pylori, Reflux esophagitis, Correlation
表1 2组患者基础资料及Hp感染率比较
组别 例数 性别 年龄（岁，） BMI（kg/m2，） Hp感染率[例（%）]
男性 女性
观察组 325 176 149 49.48±12.37 23.99±2.54 171（52.6）
对照组 285 139 146 46.04±13.26 22.38±2.42 160（56.1）
统计量 2.923 3.435 1.338 0.760
P值 0.087 0.064 0.248 0.383
表2 不同分组间（分级）Hp感染对比
组别 例数 Hp阳性 Hp阴性 统计量 P值
RE组 198 83（41.9%） 115（58.1%） χ2=9.452 0.002
对照组 285 160（56.1%） 125（43.9%）
观察组GERD亚型 χ2=36.256 0.000
NERD 122 87（71.3%） 35（28.7%）
LA-A 107 56（52.3%） 51（47.7%）
LA-B 65 23（35.4%） 42（65.6%）
LA-C 23 4（17.4%） 19（82.6%）
表3 GERD不同等级患者Hp感染情况
等级 例数 Hp（－） Hp感染程度 统计量 P值
+ ++ +++ ++++
NERD 122 35 15 31 20 21 χ2=4.625 0.866
LA-A 107 51 10 21 16 9
LA-B 65 42 2 7 6 8
LA-C 23 19 1 1 1 1
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