分析重度反流性食管炎合并消化性溃疡患者的临床和内镜检查特点。

收集2015年 3月至 2021年2月新疆维吾尔自治区人民医院消化科收治的重度反流性食管炎患者的临床资料，分为合并消化性溃疡和无合并消化性溃疡2组，分析患者的性别、年龄、幽门螺杆菌感染状况。分析重度反流性食管炎合并消化性溃疡患者的溃疡部位和分期。

重度反流性食管炎1866例患者中, 334例合并消化性溃疡，占重度反流性食管炎的17.90%，男女比例 4.39∶1, 与无合并消化性溃疡患者相比性别构成差异有统计学意义(P<0.01)，年龄无统计学意义(P>0.05)。患者发病高峰年龄在 40~70岁，合并消化性溃疡中十二指肠球部溃疡260例（77.84%），消化性溃疡并上消化道梗阻108例（32.34%）；活动期溃疡186处（53.76%）。重度反流性食管炎合并消化性溃疡幽门螺杆菌感染269例（80.54%），重度反流性食管炎无合并消化性溃疡幽门螺杆菌感染 735例（47.98%），差异有统计学意义(P<0.01)。

重度反流性食管炎常合并消化性溃疡，且男性明显多于女性患者，发病高峰年龄在40~70岁，以十二指肠球部溃疡多见，多为活动期溃疡，常合并上消化道梗阻，幽门螺杆菌感染率高。

To analyze the clinical and endoscopic features of patients with severe reflux esophagitis complicated with peptic ulcer.

Data on severe reflux esophagitis diagnosed and treated in the Department of Gastroenterology of Xinjiang Uygur Autonomous Region People's Hospital from March 2015 to February 2021 were collected and divided into 2 groups,combined with peptic ulcer and without combined with peptic ulcer,and the patients' gender,age,and status of Helicobacter pylori infection were analyzed. The ulcer sites and stages of patients with severe reflux esophagitis combined with peptic ulcer were analyzed.

Among 1866 patients with severe reflux esophagitis, 334 patients had combined peptic ulcers, accounting for 17.90% of the patients with severe reflux esophagitis, and the male-to-female ratio was 4.39∶1, which showed a certain difference in the gender composition compared with that of the patients with no combined peptic ulcers (P<0.01), and there was no significant difference in the age (P>0.05). The peak age of onset of the disease was between 40 and 70 years old. Among the combined peptic ulcers, there were 260 cases of duodenal bulb ulcers, accounting for 77.84%; 186 cases of active ulcers, accounting for 53.76%; 108 cases of peptic ulcers with upper gastrointestinal obstruction, accounting for 32.34%,and 269 cases of Helicobacter pylori infections in severe reflux esophagitis combined with peptic ulcers, accounting for 80.54%;735 cases of severe reflux esophagitis without combined peptic ulcers Helicobacter pylori infection, accounting for 47.98%;there was a certain difference between the two groups (P<0.01).

The prevalence rate of severe reflux esophagitis was significantly higher in males than in faremals. The peak age of patients is 40 to 70 years old. Ulcers in the duodenal bulb are common, mostly active ulcers, and are often combined with upper gastrointestinal obstruction and a high rate of H. pylori infection.