Experience in perioperative diagnosis and treatment of children with respiratory symptoms of gastroesophageal reflux disease

doi:10.3877/cma.j.issn.2095-8765.2022.01.004

Abstract

Abstract:

Objective

To evaluate the clinical value of adult gastroesophageal reflux disease screening in children over 5 years old and in the treatment of acid suppression.

Method

From March 2012 to June 2019, in the Department of Pediatric Surgery, People's Hospital of Xinjiang Uygur Autonomous Region Children in the operation period were enrolled in the study. 109 children with gastroesophageal reflux disease were selected by the gastroesophageal reflux disease questionnaire (GERD-Q) scale. 60 children with non-reflux were used as the control group. The correlation and efficacy between the general clinical symptoms and test indicators of the two groups were observed.

Results

43 cases of children who were misdiagnosed as bronchitis treatment group, the symptoms of cough and cough were obviously improved on the second day after intravenous omeprazole inhibition treatment. The time required for complete control of symptoms was 4.0±1.2 days. For the 39 children diagnosed, the time required for symptom control after anti-inflammatory±acid suppression treatment was (5.0±1.6) days. In 27 case with misdiagnosis of asthma, the symptoms of cough and cough were obviously improved on the second day after intravenous omeprazole inhibition treatment. The time required for complete control of symptoms was (6.0±2.1) days. The average value of the GERD-Q rating scale in the experimental group was (11.7±2.6) points, while the average in the control group was [(6.4±1.8) points; P＜0.05]. The mean score of the GERD-Q score of the children in the experimental group was (6.1±1.2) points after treatment, which was statistically significant (P＜0.05), but not statistically significant (P＞0.05).

Conclusion

GERD-Q has the effect of screening for gastroesophageal reflux disease in children over 5 years old. Early diagnosis and timely acid suppression treatment can control airway disease caused by gastroesophageal reflux disease, improve life treatment of children, and shorten hospitalization time.

Key words: Child, extra-oesophageal symptoms, gastroesophageal reflux

Aziguri·Mamaiti, Aimaijiang Jena·Guli, Ling Zhou, Hejun, Shuixue Li. Experience in perioperative diagnosis and treatment of children with respiratory symptoms of gastroesophageal reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2022, 09(01): 19-22.

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Figures/Tables 2

References 6

1	Nabi Z, Reddy DN. Update on endoscopic approaches for the management of gastroesophageal reflux disease[J]. Gastroenterol Hepatol (N Y), 2019, 15(7):369-376.
2	Shih YS, Tsai CH, Li TC, et al. Effect of wu chu yu tang on gastroesophageal reflux disease: Randomized, double-blind, placebo-controlled trial[J]. Phytomedicine, 2019, 56:118-125
3	Majid A, Kheir F, Alape D, et al. The prevalence of gastroesophageal reflux in patients with excessive central airway collapse[J]. Chest, 2019, 155(3):540-545.
4	Hsing TYC, Tsai IJ, Hsu CT, et al. Role of esophageal manometry in children with refractory gastroesophageal refluxsymptoms[J]. Pediatr Int, 2019, 61(8):807-811.
5	Sevencan NO, Cesur O, Cakar M, et al. Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease[J]. Am J Transl Res, 2019, 11(5):3176-3186.
6	Deal L,Gold BD, Gremse DA, et al. Age-specific questionnaires distinguish GERD symptom frequency and severity in infants and young children: development and initial validation[J]. .J Pediatr Gastroenterol Nutr, 2005, 41(2):178-185.

变量	试验组	对照组	P值
性别［例（%）］			0.038
男性患儿	70（64.2）	35（58.3）
女性患儿	39（35.8）	25（41.7）
年龄［例（%）］			0.175
5~7岁	51（46.8）	27（45）
7~16岁	58（53.2）	33（55）
发烧［例（%）］			0.029
有	47（43.1）	13（21.7）
无	62（56.9）	47（78.3）
白细胞总数［例（%）］			0.089
升高	35（32.1）	21（35）
正常	74（67.9）	39（65）
单核淋巴总数［例（%）］			0.172
升高	37（33.9）	18（30）
正常	72（66.1）	42（70）
中性粒细胞［例（%）］			0.042
升高	46（42.2）	16（26.7）
正常	63（57.8）	44（73.3）
凝血功能［例（%）］			0.193
异常	31（28.4）	15（25）
正常	78（71.6）	45（75）
术后用药时间［例（%）］			0.086
24 h	42（38.5）	20（33.3）
48 h	36（33.0）	25（41.7）
72 h	31（28.5）	15（25）
平均住院时间（d）	9.3±4.3	6.5±3.1	0.081
术前食管pH测定［例（%）］			0.022
升高	72（66.1）	18（30）
正常	37（33.9）	42（70）

变量	试验组	对照组	P值
性别［例（%）］			0.038
男性患儿	70（64.2）	35（58.3）
女性患儿	39（35.8）	25（41.7）
年龄［例（%）］			0.175
5~7岁	51（46.8）	27（45）
7~16岁	58（53.2）	33（55）
发烧［例（%）］			0.029
有	47（43.1）	13（21.7）
无	62（56.9）	47（78.3）
白细胞总数［例（%）］			0.089
升高	35（32.1）	21（35）
正常	74（67.9）	39（65）
单核淋巴总数［例（%）］			0.172
升高	37（33.9）	18（30）
正常	72（66.1）	42（70）
中性粒细胞［例（%）］			0.042
升高	46（42.2）	16（26.7）
正常	63（57.8）	44（73.3）
凝血功能［例（%）］			0.193
异常	31（28.4）	15（25）
正常	78（71.6）	45（75）
术后用药时间［例（%）］			0.086
24 h	42（38.5）	20（33.3）
48 h	36（33.0）	25（41.7）
72 h	31（28.5）	15（25）
平均住院时间（d）	9.3±4.3	6.5±3.1	0.081
术前食管pH测定［例（%）］			0.022
升高	72（66.1）	18（30）
正常	37（33.9）	42（70）

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