To investigate the relationship between different endoscopic subtypes of gastroesophageal reflux disease and H. pylori infection.

A total of 325 adult patients who were diagnosed as gastroesophageal reflux disease due to acid reflux and heartburn in our hospital from March 2021 to June 2022 and underwent gastroscopy were selected as the observation group, while 285 asymptomatic healthy persons who underwent gastroscopy during the same period were selected as the control group, and helicobacter pylori infection was compared between the two groups. Meanwhile,the correlation between different subtypes of gastroesophageal reflux disease and helicobacter pylori infection was analyzed.

There were no significant differences in age, gender and body mass index between two groups. The Hp infection rate between the observation group and the control group was 52.6% and 56.1%, and there was no significant difference between the two groups (P>0.05). However, the Hp infection rate of the patients with reflux esophagitis was 41.9%, and the difference was statistically significant (P<0.05). In the observation group, there were 122 cases of non-erosive esophagitis, 107 cases of grade A, 67 cases of grade B, 23 cases of grade C, 3 cases of grade D and 5 cases f Barrett's oesophagus. The infection rates of Hp were 71.3%、52.3%、35.4%、17.4%、0/3和1/5, and there were significant differences among all groups (P<0.05).

In patients with reflux esophagitis, the infection rate of Hp decreases with the increase of disease grade, which may delay the progression of the disease.However, there was no obvious correlation with its degree of infection.