Clinical and pathological characteristics analysis of reflux esophagitis combined with different types of Helicobacter pylori

doi:10.3877/cma.j.issn.2095-8765.2024.02.006

Abstract

Abstract:

Objective

To explore the correlation analysis of clinical symptoms, disease severity and serum gastric function indicators of different types of Helicobacter pylori (Hp) infection combined with reflux esophagitis (RE).

Methods

A total of 580 patients diagnosed with reflux esophagitis in People's Hospital of Xinjiang Uygur Autonomous Region from May 2021 to May 2023 were enrolled as the study subjects. According to the Hp antibody typing test, they were divided into type Ⅰ Hp infection group, type Ⅱ Hp infection group and negative group, and the clinical data and serological indicators of each group were analyzed.

Results

The Hp infection rate in RE patients was 20.35%. The typical and atypical clinical symptoms of typeⅠ Hp infection group were higher than those of typeⅡ Hp infection group (P<0.05); the pathological severity of typeⅠ Hp infection group was higher than that of typeⅡ Hp infection group and negative group, and the difference was statistically significant (P<0.05); compared with type Ⅱ Hp infection group and negative group, the serum levels of PGⅠ, PGⅡ, PGR and G-17 in typeⅠ Hp infection group were increased, and the difference was statistically significant (P<0.05).

Conclusion

The Hp infection rate in RE patients is low, and different types of Hp symptomatic infection have different effects on the development of RE disease.

Key words: Reflux esophagitis, Helicobacter pylori, Virulence factors, Serum gastric function test

Qi Jiang, Weidong Liu, Kuerbanjiang Aihemaijiang·, Wenjia Hui, Mengxia Zhang, Zi Qiong Li, Feng Gao. Clinical and pathological characteristics analysis of reflux esophagitis combined with different types of Helicobacter pylori[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2024, 11(02): 95-99.

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References 24

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组别	n	倾向性评分匹配前			倾向性评分匹配后
		年龄[岁，M(Q₁，Q₃)]	性别[例(%)]		年龄[岁，M(Q₁，Q₃)]	性别[例(%)]
		年龄[岁，M(Q₁，Q₃)]	男性	女性	年龄[岁，M(Q₁，Q₃)]	男性	女性
Ⅰ型Hp组	123	57(50, 65)	86(69.92)	37(30.08)	58(50, 65)	79(69.91)	34(30.09)
Ⅱ型Hp组	133	57(50, 64)	91(68.42)	42(31.58)	55(48.5, 64)	74(70.48)	31(29.52)
阴性组	388	60(52, 67)	269(69.33)	119(30.67)	59(51, 67)	252(69.61)	110(30.39)
χ²/Z		7.45	0.07		5.47	0.03
P值		0.024	0.966		0.065	0.985

组别	n	倾向性评分匹配前			倾向性评分匹配后
		年龄[岁，M(Q₁，Q₃)]	性别[例(%)]		年龄[岁，M(Q₁，Q₃)]	性别[例(%)]
		年龄[岁，M(Q₁，Q₃)]	男性	女性	年龄[岁，M(Q₁，Q₃)]	男性	女性
Ⅰ型Hp组	123	57(50, 65)	86(69.92)	37(30.08)	58(50, 65)	79(69.91)	34(30.09)
Ⅱ型Hp组	133	57(50, 64)	91(68.42)	42(31.58)	55(48.5, 64)	74(70.48)	31(29.52)
阴性组	388	60(52, 67)	269(69.33)	119(30.67)	59(51, 67)	252(69.61)	110(30.39)
χ²/Z		7.45	0.07		5.47	0.03
P值		0.024	0.966		0.065	0.985

	n	典型症状	非典型症状
Ⅰ型Hp组	113	55(48.67)*	70(61.95)*
Ⅱ型Hp组	105	34(32.38)	48(45.71)#
阴性组	362	143(39.50)	207(57.18)
χ²		6.12	6.34
P		0.047	0.042

	n	典型症状	非典型症状
Ⅰ型Hp组	113	55(48.67)*	70(61.95)*
Ⅱ型Hp组	105	34(32.38)	48(45.71)#
阴性组	362	143(39.50)	207(57.18)
χ²		6.12	6.34
P		0.047	0.042

组别	例数	A级	B级	C级	D级
Ⅰ型Hp组	113	57(50.44) *#	40(35.40) *#	10(8.85) *#	6(5.31) *#
Ⅱ型Hp组	105	74(70.48)	18(17.14)	8(7.62)	5(4.76)
阴性组	362	252(69.61)	72(19.89)	32(8.84)	6(1.66)
χ²值		21.020
P值		0.001

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