To analyze the clinical and endoscopic features of patients with reflux esophagitis complicated with peptic ulcer.

The date of 3311 patients’ gender, age, the location and stage of peptic ulcer, combined upper gastrointestinal obstruction, esophageal hiatal hernia and the infection of Helicobacter pylori with reflux esophagitis complicated with peptic ulcer were retrospectively analyzed in the Gastroenterology Department of the People’s Hospital of Xinjiang Uygur Autonomous Region from March 2015 to February 2021. Patients were stratified into a mild RE combined with PU group (2977 cases, LA grades A and B) and a severe RE combined with PU group (334 cases, LA grades C and D) according to the Los Angeles (LA) classification system. The chi-square test was used to compare between-group differences in gender, concomitant upper gastrointestinal obstruction, concurrent hiatal hernia and Helicobacter pylori infection status, while the independent-samples t-test was applied for intergroup comparison of age.

3311 case of reflux esophagitis complicated with peptic ulcer, the male to female ratio was 3.74:1 (2612 vs 699), the mild to severe reflux esophagitis ratio was 8.91:1 (2977 vs 334); There was no statistically significant difference in the male-to-female ratio between the two groups (P>0.05). The difference in age between males and females was statistically significant (50.82±13.27 vs 57.76±15.11; t=-7.72, P<0.001). There were 2471 patients with duodenal bulbar ulcer, accounting for 74.63%; Of the 3540 ulcers, 2808 (79.32%) were in the active or healing stage. 157 and 108 cases were developed upper gastrointestinal obstruction, There was a statistical difference between them (P<0.001). 262 and 67 cases of combined hiatal hernia of the esophagus, which were statistically different from each other (P<0.001), 73.06% and 80.54% were the infection rate of Helicobacter pylori, which were statistically different from each other (χ²=8.690, P=0.003).

In patients with reflux esophagitis complicated by peptic ulcer, males are significantly more affected than females. Duodenal bulb ulcers are the most common type, mostly in the active or healing stage. The infection rate of Helicobacter pylori is high. Severe reflux esophagitis complicated by peptic ulcer is more often associated with upper gastrointestinal obstruction and hiatal hernia.