To clarify the current awareness status of laryngopharyngeal reflux disease (LPRD) among County-level Hospitals of Southern Xinjiang, and provide a scientific basis for formulating the disease’s prevention and treatment strategies.

A total of 10 county-level medical institutions were enrolled using the cluster sampling method. A cross-sectional survey was conducted among physicians in the departments of otorhinolaryngology, gastroenterology, and gastrointestinal surgery to investigate their awareness of laryngopharyngeal reflux disease (LPRD). Chi-square test and multivariate Logistic regression analysis were performed to identify the factors influencing LPRD awareness. Receiver operating characteristic (ROC) curves were plotted and the area under the curve (AUC) was calculated to evaluate the predictive efficacy of the multivariate Logistic regression model.

171 physicians were surveyed. While 84.21% had heard of LPRD, overall awareness was only 13.5%, with textbooks (72.9%) the most common source. 15.2% knew the reflux symptom index; 33.92% could correctly apply the laryngeal reflux sign scale; 20.5% recognized 24-hour MII-pH monitoring as the diagnostic "gold standard" ; 14.6% knew proton pump inhibitors as first-line therapy. Educational background, specialty, and title influenced LPRD knowledge: Bachelor’s or above degree holders had higher awareness than lower-educated counterparts (OR=12.689); gastrointestinal surgeons had lower awareness than otolaryngologists (OR=0.191); intermediate (OR=15.719) and senior (OR=95.415) title holders outperformed juniors.

Though most relevant specialty physicians in county hospitals are aware of LPRD, overall understanding is suboptimal, needing enhanced screening and treatment capabilities.