To analyze the clinical and endoscopic features of patients with severe reflux esophagitis complicated with peptic ulcer.

Data on severe reflux esophagitis diagnosed and treated in the Department of Gastroenterology of Xinjiang Uygur Autonomous Region People's Hospital from March 2015 to February 2021 were collected and divided into 2 groups,combined with peptic ulcer and without combined with peptic ulcer,and the patients' gender,age,and status of Helicobacter pylori infection were analyzed. The ulcer sites and stages of patients with severe reflux esophagitis combined with peptic ulcer were analyzed.

Among 1866 patients with severe reflux esophagitis, 334 patients had combined peptic ulcers, accounting for 17.90% of the patients with severe reflux esophagitis, and the male-to-female ratio was 4.39∶1, which showed a certain difference in the gender composition compared with that of the patients with no combined peptic ulcers (P<0.01), and there was no significant difference in the age (P>0.05). The peak age of onset of the disease was between 40 and 70 years old. Among the combined peptic ulcers, there were 260 cases of duodenal bulb ulcers, accounting for 77.84%; 186 cases of active ulcers, accounting for 53.76%; 108 cases of peptic ulcers with upper gastrointestinal obstruction, accounting for 32.34%,and 269 cases of Helicobacter pylori infections in severe reflux esophagitis combined with peptic ulcers, accounting for 80.54%;735 cases of severe reflux esophagitis without combined peptic ulcers Helicobacter pylori infection, accounting for 47.98%;there was a certain difference between the two groups (P<0.01).

The prevalence rate of severe reflux esophagitis was significantly higher in males than in faremals. The peak age of patients is 40 to 70 years old. Ulcers in the duodenal bulb are common, mostly active ulcers, and are often combined with upper gastrointestinal obstruction and a high rate of H. pylori infection.