Research progress of oxidative stress, NLRP-3 inflammasome and pyroptosis in esophageal inflammatory injury

doi:10.3877/cma.j.issn.2095-8765.2023.03.009

Abstract

Abstract:

Inflammatory injury of the esophagus often results from retrograde flow of contents from the stomach and duodenum into the esophagus, inducing discomfort symptoms and pathological changes in the esophageal mucosa. Gastroesophageal reflux disease (GERD) is a chronic inflammatory disease of the esophagus that is stimulated by repeated acid/bile acids, which may increase the risk of cancer through oxidative damage pathways. Gastric burning and reflux are typical symptoms of GERD, with an estimated number of over 100 atypical manifestations, including non cardiac chest pain, bronchopulmonary or otolaryngological symptoms, and tooth erosion. The understanding of the cellular and molecular mechanisms underlying this transformation is still limited. GERD induces the accumulation of reactive oxygen species oxidative stress in esophageal tissue and chronic inflammatory local infiltration response, in which inflammasomes play an important regulatory role. Pyroptosis is widely involved in the occurrence and development of digestive system diseases. This article mainly reviews the current research status of the mechanism of oxidative stress, NOD like receptor protein inflammasome and pyroptosis in the occurrence and development of esophageal oxidative damage and inflammation at home and abroad, providing a theoretical basis for its further clinical diagnosis and treatment and mechanism exploration.

Key words: Inflammatory injury of the esophagus, Gastroesophageal reflux disease, Oxidative stress, Inflammasome, Pyroptosis

Wulayin Abulikemu·, Yongkang Wang, Yisireyili Maimaiti·, Zhaoyang Wu, Abudureyimu Kelimu·. Research progress of oxidative stress, NLRP-3 inflammasome and pyroptosis in esophageal inflammatory injury[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(03): 151-155.

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