切换至 "中华医学电子期刊资源库"

中华胃食管反流病电子杂志 ›› 2015, Vol. 02 ›› Issue (03) : 135 -137. doi: 10.3877/cma.j.issn.1674-6899.2015.03.003

所属专题: 文献

论著

埃索美拉唑联合莫沙必利治疗贲门癌术后反流性食管炎的临床疗效观察
杨春1()   
  1. 1. 610072 成都,四川省医学科学院 四川省人民医院胃肠外科
  • 收稿日期:2015-07-16 出版日期:2015-08-15
  • 通信作者: 杨春

Observation of clinical efficacy of esomeprazole in combination of mosapride in the treatment of reflux esophagitis after resection of cardiac carcinoma

Chun Yang1,()   

  1. 1. Department of Gastrointestinal Surgery, Sichuan Provincial People′s Hospital, Chengdu 610072, China
  • Received:2015-07-16 Published:2015-08-15
  • Corresponding author: Chun Yang
  • About author:
    Corresponding author: Yang Chun, Email:
引用本文:

杨春. 埃索美拉唑联合莫沙必利治疗贲门癌术后反流性食管炎的临床疗效观察[J]. 中华胃食管反流病电子杂志, 2015, 02(03): 135-137.

Chun Yang. Observation of clinical efficacy of esomeprazole in combination of mosapride in the treatment of reflux esophagitis after resection of cardiac carcinoma[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2015, 02(03): 135-137.

目的

探讨埃索美拉唑联合莫沙必利治疗贲门癌术后反流性食管炎的临床效果。

方法

76例贲门癌术后反流性食管炎患者随机分为两组,治疗组38例给予埃索美拉唑联合莫沙必利,对照组38例给予莫沙必利。观察8周后的临床症状改善及内镜下病变情况。

结果

治疗组患者8周后内镜下治愈率占78.95%,对照组仅占26.32%,两组间比较差异有统计学意义(P<0.001),两组患者的临床症状改善方面差异有统计学意义(P=0.016)。

结论

埃索美拉唑联合莫沙必利治疗贲门癌术后反流性食管炎较莫沙必利单药疗效显著,值得临床推广。

Objective

To explore the clinical efficacy of esomeprazole in combination of mosapride in the treatment of reflux esophagitis after resection of cardiac carcinoma.

Methods

76 patients with reflux esophagitis after resection of cardiac carcinoma were randomized into two group, treatment group and Control group.The treatment group(n=38)received treatment of esomeprazole plus mosapride, and the control group(n=38)received treatment of mosapride only.Improvements of clinical symptoms and endoscoic pathological changes after 8 weeks were observed.

Results

Clinical efficacy and and endoscope results of treatment group were better than control group, with statistically difference(P<0.05).

Conclusion

Esomeprazole in combination of mosapride shows more significant clinical efficacy then mosapride only in the treatment of reflux esophagitis after resection of cardiac carcinoma, which is worth a clinical promotion.

表1 两组反流性食管炎患者临床资料比较
表2 两组反流性食管炎患者的临床症状缓解情况[例(%)]
表3 两组反流性食管炎患者的内镜下病变改善情况[例(%)]
表4 两组反流性食管炎患者治疗前后临床症状评分比较(分,±s)
1
Chandrasoma P, Wickramasinghe K, Ma Y, et al.Adenocarcinomas of the distal esophagus and " gastric cardia" are predominantly esophageal carcinomas[J]. Am J Surg Pathol, 2007, 31(4): 569-575.
2
Wang CY, Hsu HK, Chang HC, et al.Reflux esophagitis after proximal subtotal gastrectomy[J]. Zhonghua Yi Xue Za Zhi(Taipei), 1997, 59(6): 348-353.
3
Hampel H, Abraham NS, El-Serag HB, et al.Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications[J]. Ann Intern Med, 2005, 143(3): 199-211.
4
Dunbar KB, Souza RF, Spechler SJ, et al.The Effect of Proton Pump Inhibitors on Barrett′s Esophagus[J]. Gastroenterol Clin North Am, 2015, 44(2): 415-424.
5
Jung DH, Yun GW, Lee YJ, et al.Clinicopathologic Analysis of Proton Pump Inhibitor-Responsive Esophageal Eosinophilia In Korean Patients[J]. Gut Liver, 2016, 10(1): 37-41.
6
Zhou Y, Wu XD, Shi Q, et al.Coexistence of gastrointestinal stromal tumor, esophageal and gastric cardia carcinomas[J]. World J Gastroenterol, 2013, 19(12): 2005-2008.
7
Dvorak K, Fass R, Dekel R, et al.Esophageal acid exposure at pH<or=2 is more common in Barrett′s esophagus patients and is associated with oxidative stress[J]. Dis Esophagus, 2006, 19(5): 366-372.
8
Ichikawa H, Sugimoto M, Sugimoto K, et al.Rapid metabolizer genotype of CYP2C19 is a risk factor of being refractory to proton pump inhibitor therapy for reflux esophagitis[J]. J Gastroenterol Hepatol, 2015.
9
Pauwels A, Altan E, Tack J, et al.The gastric accommodation response to meal intake determines the occurrence of transient lower esophageal sphincter relaxations and reflux events in patients with gastro-esophageal reflux disease[J]. Neurogastroenterol Motil, 2014, 26(4): 581-588.
[1] 黄勇, 郑智, 张海翘, 王龙, 辛城霖, 刘小野, 尹杰, 张军. 近端胃切除术后消化道重建方式的研究进展[J]. 中华普外科手术学杂志(电子版), 2023, 17(04): 456-460.
[2] 张姝翌, 王树森, 董默, 石磊, 李彦如, 李文. 埃索美拉唑预防氯吡格雷相关性胃黏膜损伤的研究[J]. 中华胃肠内镜电子杂志, 2018, 05(01): 38-40.
[3] 张振松, 贺跃, 张学军, 吴秀华, 李东印. 腹腔镜食管裂孔疝修补联合胃底折叠术54例临床疗效分析[J]. 中华胃食管反流病电子杂志, 2017, 04(02): 52-55.
[4] 美丽克扎提·安扎尔, 米热阿依·阿不都哈的尔, 高峰. 体质指数与反流性食管炎之间关系的研究[J]. 中华胃食管反流病电子杂志, 2016, 03(04): 145-147.
[5] 王斌, 张伟, 刘晟, 宋鑫, 祝炜, 江道振, 仇明. 一种新型建立胃食管反流病的动物模型的方法:导尿管球囊扩张术[J]. 中华胃食管反流病电子杂志, 2014, 01(01): 52-55.
阅读次数
全文


摘要