分析重症监护室住院机械通气患者GER与呼吸机相关性肺炎（VAP）发生的相关性。

收集2016年5月至2017年6月，新疆维吾尔自治区人民医院重症监护室住院并进行机械通气治疗的65例重症患者，分别在机械通气治疗第1、2、3及5天时收取气管分泌物，采用ELISA法检测标本中胃蛋白酶浓度，并对患者进行临床肺部感染分析，以分析胃蛋白酶浓度与VAP关系。

65例患者在第1天气管胃蛋白酶阳性检出率为12.31%，第2天阳性检出率为40.00%，第3天阳性检出率为66.15％，第5天阳性检出率80.00%，随机械通气时间延长而阳性检出率增高（P<0.05）；65例患者中有28例发生VAP，VAP患者第2、3及5天时气管分泌物中胃蛋白酶浓度均显著高于非VAP患者，差异有统计学意义（P<0.05）；VAP患者气管胃蛋白酶浓度与VAP发生呈正相关（R>0，P<0.05）。

随机械通气时间延长而阳性检出率增高，VAP患者气管胃蛋白酶浓度显著高于非VAP患者，VAP患者气管胃蛋白酶浓度与CPIS评分正相关。

To analyze the correlation between gastroesophageal reflux and ventilator pneumonia associated (VAP) in mechanically ventilated patients in intensive care unit (ICU).

From May 2016 to June 2017 of the people's Hospital of Xinjiang Uygur Autonomous Region, with mechanical ventilation in ICU 65 cases of patients, collect of the tracheal secretions 1,2,3,5 days respectively, which were detected by ELISA specimens, and analysis of patients with clinical pulmonary infection, and to analyze the concentration of pepsin the relationship between VAP.

All patients in the first tube weather pepsin positive rate was 12.31% in second days, the positive rate was 40% in third days, the positive rate was 66.15% in fifth days, the positive rate is 80%, with prolonged mechanical ventilation and positive rate increased (P<0.05); There were 28 cases of VAP patients, and 2 days, 3 days, 5 days of pepsin in tracheal secretion were significantly higher than that of non-VAP patients, the difference was statistically significant (P<0.05); VAP patients with tracheal pepsin concentration positively correlated with VAP (R>0, P<0.05).

The concentration of tracheal pepsin in patients with VAP was significantly higher than that in non VAP patients. And the concentration of tracheal pepsin in patients with VAP was positively related to the CPIS score.