Analysis of pulmonary function, acid reflux and esophageal dynamics in obese with obstructive sleep apnea syndrome patients

doi:10.3877/cma.j.issn.2095-8765.2020.03.007

Abstract

Abstract:

Objective

To investigate the pulmonary function, acid reflux and esophageal dynamics in obese patients with obstructive sleep apnea syndrome (OSAS).

Methods

A retrospective analysis was made of 82 obese patients who were hospitalized in the respiratory and critical care medical center in our hospital from March 2019 to December 2019. According to the clinical data, the patients who were diagnosed by PSG and met the diagnostic criteria of OSAS were included in the OSAS group (n=42 case) and non OSAS group (n=42 case). The characteristics of OSAS were analyzed by lung function, GERD questionnaire, 24-hour pH test and esophageal dynamics test.

Results

The PSG analysis showed that the AHI index of OSAS group was higher than non OSAS group, and SaO₂% were lower than non OSAS group (P＜0.05); FVC and FEV₁ in OSAS group were significantly lower than those in non OSAS group, while FRC was significantly higher than those in non OSAS group (P＜0.05); sleep disorders in OSAS group were significantly higher than OSAS group (P＜0.05); 24-hour esophageal pH test showed that the number of acid reflux, total acid reflux and DeMeester score in the OSAS group were significantly higher than those in the non OSAS group (P＜0.05); the esophageal motility test showed that the LES resting pressure in the OSAS group was lower, and the UES resting pressure was higher than that in the non OSAS group (P＜0.05).

Conclusion

OSAS in obese patients is related to the change of pulmonary function, acid reflux and esophageal motility, which can promote and influence each other.

Key words: obesity, obstructive sleep apnea syndrome, pulmonary function, acid reflux, esophageal motility

Zulipeiya·Abaidula, Anshuan Gou, Maimaiti·Yisireyili, Min Ling, Aikebaier·Aili, Ling Niu, Kelimu·Abudureyimu. Analysis of pulmonary function, acid reflux and esophageal dynamics in obese with obstructive sleep apnea syndrome patients[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2020, 07(03): 167-171.

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Figures/Tables 5

	非OSAS组（n=40）	OSAS组（n=42）	χ²/t	P
性别（男/女）	23/17	24/18	0.685*	＞0.05
年龄（岁）	38.2±6.0	37.6±8.7	0.954	＞0.05
身体质量指数（ $x ¯$ ±s，kg/m²）	30.53±1.86	32.16±2.97	1.065	＞0.05
病程（ $x ¯$ ±s，个月）	6.87±2.84	9.68±3.75	1.541	＞0.05
AHI（ $x ¯$ ±s，次/h）	23.65±3.16	34.38±4.11	1.979	＜0.05
SaO₂（ $x ¯$ ±s，%）	85.43±2.15	77.74±3.69	1.853	＜0.05

	非OSAS组（n=40）	OSAS组（n=42）	χ²/t	P
性别（男/女）	23/17	24/18	0.685*	＞0.05
年龄（岁）	38.2±6.0	37.6±8.7	0.954	＞0.05
身体质量指数（ $x ¯$ ±s，kg/m²）	30.53±1.86	32.16±2.97	1.065	＞0.05
病程（ $x ¯$ ±s，个月）	6.87±2.84	9.68±3.75	1.541	＞0.05
AHI（ $x ¯$ ±s，次/h）	23.65±3.16	34.38±4.11	1.979	＜0.05
SaO₂（ $x ¯$ ±s，%）	85.43±2.15	77.74±3.69	1.853	＜0.05

指标	非OSAS组（n=40）	OSAS组（n=42）	t	P
FVC（L）	4.80±0.85	4.03±0.91	2.012	＜0.05
FEV₁（L）	3.93±0.67	3.11±0.25	1.964	＜0.05
FEV₁/FVC（%）	105.23±10.55	101.42±8.67	0.948	＞0.05
VC（L）	3.90±0.95	3.83±0.62	0.684	＞0.05
ERV（L）	1.75±0.75	1.69±0.37	0.758	＞0.05
FRC（L）	2.16±0.91	2.92±0.75	1.883	＜0.05
TLC（L）	4.61±0.51	4.56±0.40	0.865	＞0.05

指标	非OSAS组（n=40）	OSAS组（n=42）	F	P
烧心	11（27.50%）	12（28.57%）	1.587	＞0.05
反酸	10（25.00%）	10（23.81%）	1.610	＞0.05
胸骨后疼	6（15.00%）	4（9.52%）	2.107	＞0.05
反食	6（15.00%）	4（9.52%）	2.111	＞0.05
睡眠障碍	7（17.50%）	12（28.57%）^a	5.628	＜0.05

指标	非OSAS组（n=40）	OSAS组（n=42）	t	P
弱酸反流次数	24.74±3.08	20.15±2.85	1.036	＞0.05
酸反流次数	35.52±4.81	72.34±5.13	3.157	＜0.05
总酸反流次数	43.28±5.70	89.25±6.55	4.102	＜0.05
DeMeester评分	20.45±5.67	95.76±10.30	5.213	＜0.05

指标	非OSAS组（n=40）	OSAS组（n=42）	t	P
LES静息压力	18.55±2.86	8.25±1.89	2.114	＜0.05
LES残余压力	10.36±3.15	13.62±2.48	0.635	＞0.05
UES静息压力	74.62±12.25	98.32±10.47	1.915	＜0.05
UES残余压力	13.65±3.17	15.63±2.60	0.987	＞0.05

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