To explore the risk factors of intestinal metaplasia Barrett's esophagus (BE).

The clinical data of 55 patients with intestinal metaplasia type BE and 110 patients with non-intestinal metaplasia type BE who were matched by gender and living conditions and treated in our hospital from January 2017 to January 2020 were collected. The basic condition, lifestyle intervention and clinical pathological parameters of the two groups were analyzed retrospectively, meanwhile the differences of clinical data between the two groups were compared. Logistic regression analysis was used to screen the risk factors related to the occurrence and development of intestinal metaplasia type BE.

The detection rate of intestinal metaplasia type BE in our hospital was 3.7% (55 cases), of which 56.4% (31 cases) were males and 43.6% (24 cases) were females. The average age was 57.73±6.54 years old. There were significant differences in age, body mass index (BMI), gastroesophageal reflux disease (GERD) symptoms, esophageal hiatus hernia, family history of esophageal cancer, serum helicobacter pylori(HP) infection status and metaplastic columnar epithelium length between intestinal metaplasia type and non-intestinal metaplasia type of BE, however, there was no statistical significance in smoking, alcohol consumption, caffeine intake, tea drinking habit, diagnostic history of colonic adenoma, family history of BE and colorectal cancer. Age ≥50 years (P=0.031, OR=3.027, 95% CI: 1.107-8.278), BMI ＞25 kg/m² (P=0.029, OR=2.300, 95% CI: 1.089-4.856), and family history of esophageal cancer (P=0.020, OR=2.420, 95% CI: 1.152-5.084) were risk factors for intestinal metaplasia type of BE.

Age ≥50 years old, high BMI and family history of esophageal cancer are the risk factors of BE, especially intestinal BE. We should strengthen the health publicity and management of the high-risk population with the above risk factors, pay attention to endoscopic monitoring of the digestive system, and prevent it from developing into malignant tumor.