Correlation of anxiety, depression and sleep disorders in gastroesophageal reflux disease

doi:10.3877/cma.j.issn.2095-8765.2020.04.002

Abstract

Abstract:

Objective

To analyze the mental abnormalities in patients with gastroesophageal reflux disease (GERD), and to explore the correlation between GERD and mental disorders.

Methods

A total of 40 patients who diagnosed in our hospital from December 2017 to June 2018 were selected, then further divided into non erosive reflux disease (NERD) group and refluxive esophagitis (RE) group according to clinical manifestations, GERD questionnaire score and gastrointestinal endoscopy. Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Pittsburgh sleep quality index (PSQI) were used in two groups.

Results

According to the analysis result of HAMA in the two groups, the anxiety scale of NERD group was significantly higher than that of RE group (P＜0.05);HAMD analysis shows that depression scale in NERD group was significantly higher that RE group (P＜0.05); PSQI analysis shows that sleep disorder scale in NERD group was significantly higher that RE group (P＜0.05); the correlation analysis of GerdQ score showed that anxiety, depression and sleep disorder were positively correlated with the severity of symptoms (P＜0.05).

Conclusion

The depression, anxiety and sleep disorder in NERD patients is higher than that in RE group. The scale of anxiety, depression and sleep disorder is helpful to the psychological intervention and the choice of rational drug treatment in GERD patients with mental disorders.

Key words: Gastroesophageal reflux disease, anxiety, depression, sleep disorders, questionnaire survey

Litifujiang·Maimaitiaili, Maimaiti·Yisireyili, Ababokeli·Wusiman, Muyesai·Nijiati, Nan Li, Ping Wang, Kelimu·Abudureyimu. Correlation of anxiety, depression and sleep disorders in gastroesophageal reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2020, 07(04): 202-206.

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Figures/Tables 6

组别	年龄（岁）（ $x ¯$ ±s）	性别（男/女）	身体质量指数（kg/m²）（ $x ¯$ ±s）
NERD组（n=22）	36.1±10.7	10/12	26.81±2.61
RE组（n=18）	40.2±8.1	8/10	27.83±2.54
χ²/t	-1.351	0.004^*	-1.236
P	＞0.05	＞0.05	＞0.05

组别	年龄（岁）（ $x ¯$ ±s）	性别（男/女）	身体质量指数（kg/m²）（ $x ¯$ ±s）
NERD组（n=22）	36.1±10.7	10/12	26.81±2.61
RE组（n=18）	40.2±8.1	8/10	27.83±2.54
χ²/t	-1.351	0.004^*	-1.236
P	＞0.05	＞0.05	＞0.05

组别	0~2分	3~7分	8~10分	11~14分	15~18分
NERD组（n=22）	6（27.3%）	7（31.8%）	5（22.7%）	3（13.6%）	1（4.5%）
RE组（n=18）	5（27.8%）	5（27.8%）	4（22.2%）	3（16.7%）	1（5.56%）
χ²	0.137
P	＞0.05

组别	例数	7~14分		15~21分		＞21分
组别	例数	男	女	男	女	男	女
NERD组	22	5（22.7%）	3（13.6%）	3（13.6%）	3（13.6%）	2（9.1%）	6（27.2%）
RE组	18	1（5.56%）	6（33.3%）	1（5.56%）	3（16.7%）	6（33.3%）	1（5.56%）
χ²		3.616		0.625		5.529
P值		＞0.05		＞0.05		＜0.05

组别	例数	＜7分		8~17分		18~24分
组别	例数	男	女	男	女	男	女
NERD组	22	4（18.1%）	3（13.6%）	4（18.1%）	2（9.1%）	2（9.1%）	7（31.8%）^*
RE组	18	1（5.56%）	5（27.8%）	2（11.1%）	4（22.2%）	5（27.8%）	1（5.56%）
χ²		2.236		1.333		5.402
P值		＞0.05		＞0.05		＜0.05

组别	例数	0~8分		9~15分		16~21分
组别	例数	男	女	男	女	男	女
NERD组	22	5（22.7%）	4（18.2%）	4（18.2%）	2（9.1%）	1（4.54%）	6（27.2%）^*
RE组	18	2（11.1%）	4（22.2%）	1（5.56%）	5（27.8%）	5（27.8%）	1（5.56%）
χ²		0.174		3.086		6.198
P值		＞0.05		＞0.05		＜0.05

组别	GERD症状严重程度
组别	r值	P值
焦虑状态	0.376	＜0.05
抑郁状态	0.237	＜0.05
睡眠障碍	0.281	＜0.05

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