Analysis of the characteristics of swallowing related cough and acid reflux in asthma patients

doi:10.3877/cma.j.issn.2095-8765.2021.02.007

Abstract

Abstract:

Objective

To investigate the prevalence and characteristics of swallowing related cough (SRC) in asthma patients.

Methods

A total of 94 asthmatic patients from August 2017 to November 2019 whom diagnosed with asthma in our hospital were selected as the study group, and asthma questionnaire survey was conducted to analyze whether they had SRC, as well as the related postnasal drip, heartburn, cough and acid reflux.

Results

The patients were divided two groups, 48 patients with SRC positive (51.1%) and 46 patients with SRC negative (48.9%); the main foods that causing cough in patients with SRC positive was spicy (33.3%) and sour (43.8%); the 24 hour pH monitoring showed that the weak acid reflux (%) in the proximal part of esophagus in patients with SRC positive was significantly higher than SRC negative group (P＜0.05); the frequency of cough caused by postnasal drip and heartburn was significantly higher than SRC negative group (P＜0.05).

Conclusion

SRC is common in asthmatic patients, which is closely related to postnasal drip, heartburn and acid reflux.

Key words: Asthma, Swallowing related cough, Acid reflux, Postnasal drip

Alimu·Maimaiti, Faming Tao, Zhaoyang Wu, Zulipeiya·Aibaidoula, Kelimu·Abudureyimu. Analysis of the characteristics of swallowing related cough and acid reflux in asthma patients[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2021, 08(02): 81-84.

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URL: https://zhwsgflbdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-8765.2021.02.007

https://zhwsgflbdzzz.cma-cmc.com.cn/EN/Y2021/V08/I02/81

Figures/Tables 4

指标	SRC（+）	SRC（-）
例数［例（%）］	48（51.1）	46（48.9）
性别（男性/女性）	20/28	18/28
年龄（岁， $x ¯$ ±s）	50.52±12.35	46.75±9.45
SRC出现时间［例（%）］
口腔阶段	6（12.5）	-
咽喉阶段	27（56.3）	-
食管阶段	15（31.3）	-
SRC严重程度［例（%）］
轻度	8（16.7）	-
中度	30（62.5）	-
重度	10（20.8）	-
伴反流相关症状［例（%）］	15（31.3）	-

指标	SRC（+）	SRC（-）
例数［例（%）］	48（51.1）	46（48.9）
性别（男性/女性）	20/28	18/28
年龄（岁， $x ¯$ ±s）	50.52±12.35	46.75±9.45
SRC出现时间［例（%）］
口腔阶段	6（12.5）	-
咽喉阶段	27（56.3）	-
食管阶段	15（31.3）	-
SRC严重程度［例（%）］
轻度	8（16.7）	-
中度	30（62.5）	-
重度	10（20.8）	-
伴反流相关症状［例（%）］	15（31.3）	-

指标	结果
辛辣性食物	16（33.3）
酸性食物	21（43.8）
咸性食物	4（8.3）
其他（热，冷食品）	7（14.6）

指标	SRC（+）（48例）	SRC（-）（46例）	t值	P值
弱酸反流（4＜pH＜7）次数（次）	16.78±5.65	14.23±4.36	0.984	0.256
弱酸反流（4＜pH＜7）次数（次）
酸反流（pH≤4）次数（次）	20.54±4.72	17.13±6.21	0.625	0.342
所有酸反流总次数（次）	25.67±7.85	23.27±4.69	0.719	0.451
食管近端弱酸反流（%）	48.72±8.67	29.87±7.13	2.654	0.041
食管近端酸反流（%）	31.65±6.41	25.63± 4.75	0.537	0.114
DeMeester评分（分）	15.02±2.45	12.68±1.87	0.867	0.210

指标	SRC（+）（48例）	SRC（-）（46例）	t值	P值
鼻后滴漏	20（41.7）	25（54.3）	1.525	0.052
鼻后滴漏伴咳嗽	14（29.2）	8（17.4）	2.114	0.041
烧心	5（10.4）	8（17.4）	1.042	0.105
烧心伴咳嗽	9（18.6）	5（10.9）	1.974	0.047

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