To investigate the effects of traditional Chinese medicine in refractory gastroesophageal reflux disease patients who failed in the PPI Treatment.

78 refractory GERD patients were diagnosed by their clinical symptoms and the corresponding herb medicine was prescribed.The objective exams of esophagus pressure, PH monitor, the scale scores were measured to evaluate the effect.

After 4 weeks treatment, effective rate of symptom remission was 85.8%(67/78). There were significant differences decrease in the pressure(P<0.05). The symptom scores improved after traditional Chinese medicine treatment.24-hour esophageal pH and DeMeester score before and after treatment indicate no significant difference.The resting pressure of the lower esophagus sphincter improved(P<0.05).

Chinese traditional medicine is helpful to GERD patients who failed with PPI.Herb medicine can be used as an alternative treatment in clinic.