Esophageal acid exposure and motility in patients with Barrett′s esophagus, erosive esophagitis, non-erosive reflux disease

doi:10.3877/cma.j.issn.1674-6899.2018.02.001

Abstract

Abstract:

Objective

To investigate the characteristics of esophageal acid exposure and motility in patients with Barrett′s esophagus(BE), erosive esophagitis(EE), non-erosive reflux disease(NERD).

Methods

Retrospectively analysed the high resolution manometry(HRM)and 24-hour ambulatory esophageal pH monitoring result of patients with BE, EE and NERD who were carefully selected according to the results of gastroesophageal reflux disease(GERD)questionnaire and endoscopy during December 2015 to December 2017 in People′s Hospital of Xinjiang Uyghur Autonomous Region.

Results

The measurement of acidic(pH≤4)or weak acidic(4<pH<7)esophageal reflux showed no statistical difference between 28-sample BE group, 35-sample EE group and 27-sample NERD group(P>0.05), nor did the DeMeester score or total reflux episodes(P>0.05). There was also no significant difference in the length of LES and DCI score between the 3 groups(P>0.05). Though the static pressure and residual pressure of the LES of BE group were slightly higher than that of the EE group and the NERD group, but the difference was not statistically significant(P>0.05).

Conclusion

Our findings suggest that acid measurement does not have a significant effect in identifying different clinical subtypes of GERD.Although the anti-reflux barrier function was damaged in different degrees in Barrett′s esophagus, erosive esophagitis, and non-erosive reflux disease all have, but the impact of esophageal mucosal injury on esophageal dynamics is not considerable.

Key words: Barrett esophagus, Erosive esophagitis, Non-erosive reflux disease, 24-hour Ambulatory pH Monitoring, High resolution manometry

Anzhaer Meilikezhati·, Abudouhadier Miriayi·, Feng Gao. Esophageal acid exposure and motility in patients with Barrett′s esophagus, erosive esophagitis, non-erosive reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2018, 05(02): 49-52.

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References 16

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组别	例数	年龄(岁，±s)	性别(例，男∶女)	BMI(kg/cm²，±s)
BE组	28	52.45±11.48	16∶12	25.38±5.65
EE组	35	50.42±12.12	16∶19	26.30±4.68
NERD组	27	51.20±13.28	14∶13	28.24±5.30
F值	?	0.136	?	2.354
P值	?	0.873	?	0.101

组别	例数	年龄(岁，±s)	性别(例，男∶女)	BMI(kg/cm²，±s)
BE组	28	52.45±11.48	16∶12	25.38±5.65
EE组	35	50.42±12.12	16∶19	26.30±4.68
NERD组	27	51.20±13.28	14∶13	28.24±5.30
F值	?	0.136	?	2.354
P值	?	0.873	?	0.101

组别	pH≤4(酸反流)总次数(次)	4<pH<7(弱酸反流)总次数(次)	酸反流总事件(次)	DeMeester评分(分)
BE组	23.00(16.25，43.00)	11.50(7.00，26.75)	32.50(26.00，66.00)	20.65(8.53，35.38)
EE组	24.00(12.00，38.00)	14.00(7.00，23.00)	37.00(19.50，66.00)	14.40(5.60，27.50)
NERD组	23.00(15.00，31.00)	8.00(7.00，15.00)	29.00(23.00，39.50)	12.60(3.60，27.50)
χ²值	1.21	1.75	1.08	4.81
P值	0.55	0.42	0.38	0.09

组别	pH≤4(酸反流)总次数(次)	4<pH<7(弱酸反流)总次数(次)	酸反流总事件(次)	DeMeester评分(分)
BE组	23.00(16.25，43.00)	11.50(7.00，26.75)	32.50(26.00，66.00)	20.65(8.53，35.38)
EE组	24.00(12.00，38.00)	14.00(7.00，23.00)	37.00(19.50，66.00)	14.40(5.60，27.50)
NERD组	23.00(15.00，31.00)	8.00(7.00，15.00)	29.00(23.00，39.50)	12.60(3.60，27.50)
χ²值	1.21	1.75	1.08	4.81
P值	0.55	0.42	0.38	0.09

组别	LES长度[cm，M(P25，P75)]	LES静息压(mmHg，±s)	LES残余压(mmHg，±s)	食管远端收缩积分[分，M(P25，P75)]
BE组	1.95(1.80，2.18)	15.01±8.58	7.12±4.95	939.30(582.35，1328.65)
EE组	2.10(1.90，2.50)	14.17±7.32	6.49±3.42	1120.50(823.20，2137.50)
NERD组	2.20(2.00，2.70)	11.65±6.27	6.04±4.17	1213.00(874.10，1713.90)
统计值	15.80	0.549	0.466	6.92
P	0.16	0.58	0.63	0.09

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