The infectious characteristics of virus that have been transmitted by people have been officially clarified. Now the National Health Committee has been included in the infectious diseases classified as infectious diseases stipulated by the infectious disease prevention act of People's Republic of China, and the prevention and control measures of class A infectious diseases have been taken. Due to the unknown type of virus, strong infectivity, temporary absence of special drugs and long-term isolation at home and many other reasons, a considerable number of people have abnormal psychological diseases of varying degrees of anxiety, depression and even irritability, which all cause digestive tract diseases such as acid reflux, heartburn, abdominal distention and even nausea and vomiting, especially aggravate the symptoms of patients with gastroesophageal reflux disease (GERD), and further perplex them Their daily life and quality of life. Novel coronavirus epidemic period is introduced safely for GERD patients. This article will give a general reference for clinical practice.