In today's medical era with the rise of comprehensive talent model, cultivating medical talents with solid theoretical knowledge and strong practical application ability has not only become the primary task of clinical teachers, but also put forward higher requirements for clinicians. How to integrate and apply independent subject knowledge to practice and solve clinical problems independently is not only a difficult point in clinical teaching, but also the top priority of teaching reform. This paper innovatively adopts the multi-disciplinary treatment (MDT) combined with the "cocooning" teaching method to apply it to the case of postoperative gastroesophageal reflux in patients with obesity related endometrial cancer, in order to guide the new clinical teaching.