胃食管反流病典型表现为胃灼热感、反酸，但很多患者以食管外症状为主要表现或唯一表现。食管外症状以呼吸系统症状多见，并且此类患者往往生活质量受到严重影响甚至威胁生命，但就诊率低，误诊率高。一方面由于临床医师和患者对此病认识不足，另一方面目前缺乏有效的、有循证依据的大样本前瞻性研究来证实胃食管反流与呼吸系统疾病之间的相关关系。二者的相关性及联系的具体机制尚不清晰，本文结合近年来国内外针对二者相关性的研究现状，对胃食管反流病与呼吸系统疾病的相关性的研究进展展开叙述。

Gastroesophageal reflux disease is a kind of disease characterized by heartburn, regurgitation.However, there are always some patients that do not have manifestations above, but have other extra-esophageal symptoms as their clinical manifestation.Of these extra-esophageal symptoms, respiratory system symptoms are in the majority, and such patients always have a low quality of life score, they may be misdiagnosed sometimes.The main reasons for this phenomenon are the lack knowledge of GERD and the lack of evidence-based researches on the correlation between GERD and respiratory disease.The mechanism of this correlation is still not completely clear now.This article is a review that retrospect the research progress on the correlation between GERD and respiratory disease in recent years.