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中华胃食管反流病电子杂志

中华胃食管反流病电子杂志 ›› 2019, Vol. 06 ›› Issue (03) : 131 -134. doi: 10.3877/cma.j.issn.2095-8765.2019.03.004

所属专题： 文献；

论著

持续均匀性肠内营养支持对胃食管反流患者免疫功能及短期转归的影响
刘菁1, 范旻1, 王志2,†()   
  1. 1. 830001　乌鲁木齐，新疆维吾尔自治区人民医院临床营养研究所
    2. 830001　乌鲁木齐，新维吾尔自治区人民医院微创、疝和壁外科
  • 收稿日期:2018-12-25 出版日期:2019-08-15
  • 通信作者: 王志

The effect of continuous homogeneity enteral nutrition support on immune function and short-term outcome in patients with gastroesophageal reflux

Liujing1, Wangzhi1, Fanmin.2,†()   

  1. 1. Department of Research institute of clinical Nutriology, Xinjiang People's Hospital, Urmuqi 830001, China
    2. Department of Minimally Invasive Surgery & Hernia and Abdominal Wall Surgery, Xinjiang People's Hospital, Urmuqi 830001, China
  • Received:2018-12-25 Published:2019-08-15
  • Corresponding author: Fanmin.
  • About author:
    Corresponding author: Wang Zhi, Email:
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引用本文：

刘菁, 范旻, 王志. 持续均匀性肠内营养支持对胃食管反流患者免疫功能及短期转归的影响[J]. 中华胃食管反流病电子杂志, 2019, 06(03): 131-134.

Liujing, Wangzhi, Fanmin.. The effect of continuous homogeneity enteral nutrition support on immune function and short-term outcome in patients with gastroesophageal reflux[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2019, 06(03): 131-134.

目的

研究持续性肠内营养支持对胃食管反流病患者免疫功能和短期转归的影响。

方法

纳入90例胃食管反流病患者作为研究对象，随机抽签分为两组，每组各45例。两组均行奥美拉唑治疗，观察组行持续性泵入肠内营养液干预，对照组行常规鼻饲干预。比较两组患者免疫功能、营养状态及治疗后短期转归。

结果

观察组治疗后CD3＜＋和CD4＜＋显著高于对照组，CD8＜＋显著低于对照组，差异均有统计学意义（P＜0.05）。两组治疗前后CD4＜＋/CD8＜＋比较，差异均无统计学意义（P＞0.05）。两组治疗后反流次数、反流时间、pH＜4时间、LESP及LESL水平均显著低于治疗前，差异有统计学意义（P＜0.05），观察组治疗后反流次数和反流时间显著低于对照组，差异有统计学意义（P＜0.05）。观察组治疗后营养状态显著优于对照组，差异有统计学意义（P＜0.05）。观察组食管反流发生率显著低于对照组，差异有统计学意义（P＜0.05）。

结论

持续均匀性肠内营养支持有助于改善胃食管反流病患者免疫功能，较传统定期鼻饲干预治疗效果更好。

关键词: 肠内营养, 胃食管反流病, 免疫功能, 短期转归
Objective

To study the effect of continuous homogeneity enteral nutrition support on immune function and short-term outcome in patients with gastroesophageal reflux.

Methods

90 cases of gastroesophageal reflux disease were included in the study and were divided into two groups by random draw, 45 cases in each group.The two groups were treated with omepr3333azole,the observation group were received the intervention of continuous pumping enteral nutrient solution,the control group were received the routine nasal feeding intervention.The immune function, nutritional status and short-term outcome after treatment were compared between the two groups.

Results

The CD3＜＋ and CD4＜＋ in the observation group were significantly higher than those in the control group,the CD8＜＋ was significantly lower than that of the control group,the difference were statistically significant (P＜0.05).There were no significant difference in the difference between the two groups of the CD4＜＋/CD8＜＋ before and after treatment (P＞0.05).The reflux times, reflux numbers, pH＜4 time, LESP and LESL levels of the two groups after treatment were significantly lower than those before treatment (P＜0.05).The reflux times and reflux numbers after treatment in the observation group were significantly lower than those of the control group (P＜0.05).The nutritional status of the observation group was significantly better than that of the control group,the difference was statistically significant (P＜0.05).The rate of esophageal reflux in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P＜0.05).

Conclusion

The continuous homogeneity of enteral nutrition support can improve the immune function of patients with gastroesophageal reflux disease, and the effect is better than that of traditional regular nasal feeding.

Key words: Enteral nutrition, Gastroesophageal reflux disease, Immune function, Short-term outcome
表1 两组患者免疫功能比较
组别 CD3＜＋（%） CD4＜＋（%） CD8＜＋（%） CD4＜＋/CD8＜＋
治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后

观察组

(n=45)

 60.28±3.79 63.14±4.92 28.97±1.83 35.04±2.23 30.19±1.85 27.96±2.04 1.35±0.57 1.42±0.52

对照组

(n=43)

 59.68±4.05 61.07±4.42 29.01±1.79 32.83±2.17 30.32±1.93 29.31±2.11 1.36±0.63 1.39±0.59
t 0.718 2.073 0.104 4.709 0.323 3.052 0.078 0.253
P 0.475 0.041 0.918 0.000 0.748 0.003 0.938 0.801
表2 两组营养状态比较 [n（%）]
组别 营养正常 营养不良风险 营养不良
观察组（n=45） 29 16 0
对照组（n=43） 19 21 3
Z -2.102
P 0.036
表3 两组患者相关临床指标比较
组别 反流次数(次/d) 反流时间（min/次） pH＜4时间(h/d) LESP(mmHg) LESL(cm)
治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后

观察组

(n=45)

 14.54±3.69 3.27±1.69 4.42±2.87 0.81±0.35 1.61±0.48 0.32±0.25 8.55±4.49 13.98±3.82 4.38±1.03 4.45±0.92

对照组

(n=43)

 15.12±4.12 5.09±2.14 4.69±3.02 1.03±0.42 1.54±0.39 0.39±0.31 9.02±4.51 12.67±3.69 4.21±0.96 4.18±0.85
t 0.696 4.438 0.430 2.674 0.749 1.169 0.490 1.635 0.800 1.428
P 0.488 0.000 0.668 0.009 0.456 0.246 0.626 0.106 0.426 0.157
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