To investigate the efficacy of Banxia xiexin Decoction combined with omeprazole on the treatment of gastroesophageal reflux disease.

The clinical data of 172 patients with gastroesophageal reflux disease(GERD)that underwent Banxia Xiexin Decoction combined with Omeprazole in the People′s Hospital of Xinjiang Uygur Autonomous Region were analyzed from January 2015 to October 2015.These patients included reflux esophagitis grade A 74 cases, grade B 47 cases, grade C 39 cases, grade D 12 cases, 23 cases combined with bile reflux, 46 cases combined with hiatal hernia.The statistics of patients who were given Banxia xiexin soup combined with omeprazole treatment were retrospectively analyzed by 24-h esophageal pH monitoring, esophageal manometry, GERD Q score and complications before treatment and 1 months after treatment.

There were no death and serious complications during hospitalization.The reflux symptoms were significantly improved after treatment, and it was significantly lower in reflux time(1.40±1.10)h, number of reflux(29.83±19.71), percentage of acid reflux time(6.47%±2.79%)and DeMeester score(7.28±4.38)than before [(2.04±1.91)h, (120.40±82.72), (9.90%±4.27%), (28.23±12.16), respectively]. GERD Q scale score(7.18±1.33)was significantly lower than preoperative(10.91±2.02), the difference was statistically significant(P<0.05). Lower esophageal sphincter(LES)pressure [minimum resting breathing(7.24±6.86)mmHg, mean resting breathing(12.91±6.89)mmHg]significantly increased than preoperative [(0.70±0.15)mmHg, (7.33±2.72)mmHg, respectively], residual pressure [average(8.16±3.82)mmHg, maximum(16.10±12.05)mmHg]significantly increased than before treatment [(4.36±1.77)mmHg, (7.49±5.15)mmHg, respectively]. Swallowing invalid(7.25%±1.04%)did not change significantly than before treatment(6.36%±3.26%), the difference was no statistically significant(P>0.05). The median follow-up was 6 months.

Banxia Xiexin Decoction combined with omeprazole has a definite therapeutic effect on the treatment of GERD with lower complications.It was worthy of clinical promotion.