Analysis of curative effect of Banxia xiexin Decoction combined with omeprazole on treatment of gastroesophageal reflux disease

doi:10.3877/cma.j.issn.1674-6899.2016.02.004

Abstract

Abstract:

Objective

To investigate the efficacy of Banxia xiexin Decoction combined with omeprazole on the treatment of gastroesophageal reflux disease.

Methods

The clinical data of 172 patients with gastroesophageal reflux disease(GERD)that underwent Banxia Xiexin Decoction combined with Omeprazole in the People′s Hospital of Xinjiang Uygur Autonomous Region were analyzed from January 2015 to October 2015.These patients included reflux esophagitis grade A 74 cases, grade B 47 cases, grade C 39 cases, grade D 12 cases, 23 cases combined with bile reflux, 46 cases combined with hiatal hernia.The statistics of patients who were given Banxia xiexin soup combined with omeprazole treatment were retrospectively analyzed by 24-h esophageal pH monitoring, esophageal manometry, GERD Q score and complications before treatment and 1 months after treatment.

Results

There were no death and serious complications during hospitalization.The reflux symptoms were significantly improved after treatment, and it was significantly lower in reflux time(1.40±1.10)h, number of reflux(29.83±19.71), percentage of acid reflux time(6.47%±2.79%)and DeMeester score(7.28±4.38)than before [(2.04±1.91)h, (120.40±82.72), (9.90%±4.27%), (28.23±12.16), respectively]. GERD Q scale score(7.18±1.33)was significantly lower than preoperative(10.91±2.02), the difference was statistically significant(P<0.05). Lower esophageal sphincter(LES)pressure [minimum resting breathing(7.24±6.86)mmHg, mean resting breathing(12.91±6.89)mmHg]significantly increased than preoperative [(0.70±0.15)mmHg, (7.33±2.72)mmHg, respectively], residual pressure [average(8.16±3.82)mmHg, maximum(16.10±12.05)mmHg]significantly increased than before treatment [(4.36±1.77)mmHg, (7.49±5.15)mmHg, respectively]. Swallowing invalid(7.25%±1.04%)did not change significantly than before treatment(6.36%±3.26%), the difference was no statistically significant(P>0.05). The median follow-up was 6 months.

Conclusion

Banxia Xiexin Decoction combined with omeprazole has a definite therapeutic effect on the treatment of GERD with lower complications.It was worthy of clinical promotion.

Key words: Gastroesophageal reflux, Treatment outcome, Integrative Medicine

Hongping Sun, Jingbo Chen. Analysis of curative effect of Banxia xiexin Decoction combined with omeprazole on treatment of gastroesophageal reflux disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2016, 03(02): 62-65.

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References 16

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组别	反流时间(h)	反流次数(次)	酸反流时间百分比(%)	长反流次数(次)	DeMeester评分(分)	GERD Q量表评分
治疗前	2.04±1.91	120.40±82.72	9.90±4.27	6.33±5.43	28.23±12.16	10.91±2.02
治疗后1月	1.40±1.10	29.83±19.71	6.47±2.79	6.20±3.48	7.28±4.38	7.18±1.33
t值	6.041	4.273	7.416	1.623	4.190	5.109
P值	0.003	0.035	0.001	0.982	0.045	0.005

组别	反流时间(h)	反流次数(次)	酸反流时间百分比(%)	长反流次数(次)	DeMeester评分(分)	GERD Q量表评分
治疗前	2.04±1.91	120.40±82.72	9.90±4.27	6.33±5.43	28.23±12.16	10.91±2.02
治疗后1月	1.40±1.10	29.83±19.71	6.47±2.79	6.20±3.48	7.28±4.38	7.18±1.33
t值	6.041	4.273	7.416	1.623	4.190	5.109
P值	0.003	0.035	0.001	0.982	0.045	0.005

组别	LES压力(mmHg)		残余压(mmHg)		无效吞咽(%)
组别	静息呼吸最小值	静息呼吸平均值	平均值	最大值	无效吞咽(%)
治疗前	0.70±0.15	7.33±2.72	4.36±1.77	7.49±5.15	6.36±3.26
治疗后1月	7.24±6.86	12.91±6.89	8.16±3.82	16.10±12.05	7.25±1.04
t值	4.198	4.627	4.859	4.132	1.742
P值	0.044	0.012	0.008	0.048	0.972

组别	LES压力(mmHg)		残余压(mmHg)		无效吞咽(%)
组别	静息呼吸最小值	静息呼吸平均值	平均值	最大值	无效吞咽(%)
治疗前	0.70±0.15	7.33±2.72	4.36±1.77	7.49±5.15	6.36±3.26
治疗后1月	7.24±6.86	12.91±6.89	8.16±3.82	16.10±12.05	7.25±1.04
t值	4.198	4.627	4.859	4.132	1.742
P值	0.044	0.012	0.008	0.048	0.972

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