The effect of gastroesophageal reflux on pulmonary function in patients with chronic obstructive pulmonary disease

doi:10.3877/cma.j.issn.1674-6899.2017.04.007

Abstract

Abstract:

Objective

To investigate the effect of GERD with COPD patients pulmonary function.

Methods

There were admitted to Department of respiration and diagnosed asthma patients 358 cases who from April 2015 to September 2017 in the people′s hospital of Xinjiang Uygur Autonomous Region, according to whether complicated with GERD were divided into GERD group and non GERD group, compared two groups of patients pulmonary function index.

Results

The incidence of GERD was 34.1%(122/358), the severity of COPD in GERD group were significantly higher than that in non GERD group, GERD group, forced expiratory volume in one second(Forced Expiratory Volume in one second FEV1, FVC, FEV1 /FVC% and PEF, FEF25%-75%)were significantly lower than those in non GERD group, and the difference There were statistical significance(P<0.05).

Conclusion

GERD is closely related to COPD, GERD affects lung function and disease severity in COPD patients, and the relationship between GERD and COPD and their mutual mechanism still need further study.

Key words: Gastroesophageal reflux disease, Pulmonary disease, chronic obstructive, Respiratory function tests

Halike Maierhaba·, Yanxia Zhao. The effect of gastroesophageal reflux on pulmonary function in patients with chronic obstructive pulmonary disease[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2017, 04(04): 169-171.

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References 14

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组别	例数	性别 [例(%)]		身高(cm，±s)	体质量(kg，±s)	BMI(kg/cm²，±s)
组别	例数	男	女	身高(cm，±s)	体质量(kg，±s)	BMI(kg/cm²，±s)
GERD组	122	55(45.1)	67(54.9)	167.45±8.84	67.53±8.26	25.25±5.47
非GERD组	236	134(56.8)	102(43.2)	166.17±8.04	68.36±8.56	24.53±6.28
t值	?	1.92		1.45	－1.23	－1.605
P值	?	0.17		0.15	0.22	0.11

组别	例数	性别 [例(%)]		身高(cm，±s)	体质量(kg，±s)	BMI(kg/cm²，±s)
组别	例数	男	女	身高(cm，±s)	体质量(kg，±s)	BMI(kg/cm²，±s)
GERD组	122	55(45.1)	67(54.9)	167.45±8.84	67.53±8.26	25.25±5.47
非GERD组	236	134(56.8)	102(43.2)	166.17±8.04	68.36±8.56	24.53±6.28
t值	?	1.92		1.45	－1.23	－1.605
P值	?	0.17		0.15	0.22	0.11

组别	例数	轻度	中度	重度	极重度
GERD	122例	10(8.2)	84(68.8)	18(14.7)	10(8.2)
非GERD	236例	67(28.3)	129(54.7)	24(10.2)	16(6.8)
χ²值	?	1.299	2.602	8.231	2.937
P值	?	0.020	0.007	<0.001	0.005

组别	例数	轻度	中度	重度	极重度
GERD	122例	10(8.2)	84(68.8)	18(14.7)	10(8.2)
非GERD	236例	67(28.3)	129(54.7)	24(10.2)	16(6.8)
χ²值	?	1.299	2.602	8.231	2.937
P值	?	0.020	0.007	<0.001	0.005

?	例数	FEV1占预计值(%)	FVC占预计值(%)	FEV1/FVC(%)	PEF(L/s)	FEF_25%-75%(L)
GERD组	122	62.4±18.9	66.6±13.2	55.4±10.2	3.22±1.02	0.49±0.18
非GERD组	236	64.6±16.7	68.2±9.5	56.7±9.98	4.22±1.48	0.65±0.34
t值	?	2.228	4.128	1.914	－2.771	3.081
P值	?	0.039	<0.001	0.036	0.007	0.005

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