To investigate the effect of preemptive analgesia with flurbiprofen axetil combined with dezocine on hemodynamics during tracheal extubation after laparoscopic of Hernia-hiata patients.

60 cases of obese patients undergoing laparoscopic cholecystectomy, ASA I-II, were randomly divided into group of flurbiprofen axetil combined with dezocine (group DF), flurbiprofen axetil group (group F) and dezocine group (group D). All patients underwent general anesthesia. In the 15 minutes before anesthesia induction, the group DF was given 0.08 mg/kg of dezocine and 0.6mg/kg of flurbiprofen axetil, group D was given 0.1mg/kg of dezocine and group F was given 1 mg/kg of flurbiprofen axetil from the vein. MAP and HR values were recorded respectively before operation (baseline, T0), at the end of the seam (T1), at the time of extubation (T2), 5min after extubation (T3) and 10min after extubation (T4). At the same time, the time of spontaneous breathing recovery, the time of eye opening, the time of extubation and the adverse reactions during extubation were recorded.

There were no significant differences among the three groups in terms of age, body mass index, operation time, extubation time and adverse reactions (P>0.05). There were no significant differences among the three groups in the MAP and HR values before operation and 10min after the extubation (P>0.05). Compared with group DF, the MAP and HR values of T2 and T3 in group D were increased significantly (P<0.05), and the MAP and HR values of T1- T3 in group F were increased significantly (P<0.05).

Preemptive analgesia with flurbiprofen axetil combined with dezocine can effectively inhibit hemodynamic fluctuations of the obese patients during extubation period and improve the recovery quality of patients with obesity. It is superior to that of single agent.