Study on the correlation between sleep apnea syndrome and gastroesophageal reflux disease in obesity patients

doi:10.3877/cma.j.issn.2095-8765.2018.03.005

Abstract

Abstract:

Objective

To investigate the correlation between OSAS and GERD in obese patients.

Methods

Retrospective analysis of clinical data of patients with obesity in the Xinjiang Uygur Autonomous Region people's Hospital from March 2015 to April 2016, perfact of pulmonary function、lung volume determination、sleeping monitoring, esophageal manometry, which according to the sleeping monitoring the results were divided into OSAS and non-OSAS group. Studying on the correlation between AHI and esophageal function.

Results

In the non-OSAS and OSAS group, the percentage of reflux correlation with AHI the (P=0.005), stomach-esophageal pressure difference and AHI was positively correlated (P<0.05); Disparity expiratory pressure and LES negative correlation with AHI (P<0.05).

Conclusion

There is a closely relationship between OSAS and GERD in obese patients, and they are reciprocal causation, which can influence each other and aggravate each other.

Key words: Sleep apnea, obstructive, Gastroesophageal reflux, Obesity, Obstructive sleep apnea hypopnea index

Maimaitiming Maimaitiaili·, Aikebaier, Hai Yan, Abudureyimu Kelimu·. Study on the correlation between sleep apnea syndrome and gastroesophageal reflux disease in obesity patients[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2018, 05(03): 113-116.

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References 13

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组别	例数	性别［例（%）］		身高（cm，±s）	体重（kg，±s）	BMI（kg/cm²，±s）
?	?	男	女	?	?	?
非OSAS	46	24（81.7）	22（18.3）	171.2±7.0	86.7±17.1	30.7±4.1
OSAS	47	26（70.1）	21（29.9）	169.9±8.2	89.2±22.3	32.8±6.8
P值	?	0.352		0.201	0.103	0.09

组别	例数	性别［例（%）］		身高（cm，±s）	体重（kg，±s）	BMI（kg/cm²，±s）
?	?	男	女	?	?	?
非OSAS	46	24（81.7）	22（18.3）	171.2±7.0	86.7±17.1	30.7±4.1
OSAS	47	26（70.1）	21（29.9）	169.9±8.2	89.2±22.3	32.8±6.8
P值	?	0.352		0.201	0.103	0.09

?	非OSAS（46例）	OSAS（47例）	相关系数	P值
食管近端反流百分比（%）	50.1［35.5-73.2］	68.2［49.1-88.2］	0.323	0.005
胃-食管压力差（mm Hg）	6.8［4.2-9.2］	8.35［6.5-12.9］	0.176	<0.001
吸呼气压力差（mm Hg）	-4.1［-4.5--3.5］	-6.8［-9.3--7.2］	-0.617	<0.001
LES静息压力（mm Hg）	19.75［9.7-35.5］	7.5［1.7-16.3］	-0.442	<0.001
远端收缩积分（mmHg?cm?s）	2023.1［1179-3129.6］	1620.8［523.8-2377.7］	-0.062	0.312
远端收缩延迟（s）	4.0［3.4-4.5］	4.2［3.3-5.4］	-0.048	0.521

?	非OSAS（46例）	OSAS（47例）	相关系数	P值
食管近端反流百分比（%）	50.1［35.5-73.2］	68.2［49.1-88.2］	0.323	0.005
胃-食管压力差（mm Hg）	6.8［4.2-9.2］	8.35［6.5-12.9］	0.176	<0.001
吸呼气压力差（mm Hg）	-4.1［-4.5--3.5］	-6.8［-9.3--7.2］	-0.617	<0.001
LES静息压力（mm Hg）	19.75［9.7-35.5］	7.5［1.7-16.3］	-0.442	<0.001
远端收缩积分（mmHg?cm?s）	2023.1［1179-3129.6］	1620.8［523.8-2377.7］	-0.062	0.312
远端收缩延迟（s）	4.0［3.4-4.5］	4.2［3.3-5.4］	-0.048	0.521

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