Objective to investigate the relationship between gastroesophageal reflux and bronchial asthma, and analyze the effect of acid suppressant drug on gastroesophageal reflux (GER, Geriatrics)

doi:10.3877/cma.j.issn.2095-8765.2019.02.005

Abstract

Abstract:

Objective

To explore the relationship between gastroesophageal reflux and bronchial asthma and the effect of acid suppressant drug on GER.

Methods

122 cases of asthma patients received from September 2016 to September 2017 in our hospital were randomly selected into the control trial. To investigate the causes of bronchial asthma in patients with questionnaire. According to the results of the investigation, 122 patients were divided into the observation group (n=49) and the control group (n=73) on the basis of whether the gastroesophageal reflux was occurring or not. The patients in observation group (n=49) were gastroesophageal reflux with bronchial asthma, the observation group of 49 patients were randomly divided into two groups, 25 patients with acid suppressant drugs (proton pump inhibitor lansoprazole) treatment, 24 patients were treated with placebo. There were no gastroesophageal reflux in 73 patients with asthma in the control group. The retrospective analysis was used to analyze the clinical data of two groups of patients. The correlation between gastroesophageal reflux and bronchial asthma was investigated by comparing the data of two groups of 122 patients with pulmonary function. To evaluate the effect of acid suppressant drugs on gastroesophageal reflux.

Results

The pulmonary function of 45 patients in the observation group was significantly worse than that of the control group (73 cases), with significant difference (P<0.05). The therapeutic effect and lung function index of 23 patients treated with acid drugs were significantly better than those in 23 cases, with significant difference (P<0.05).

Conclusion

Bronchial asthma patients are prone to gastroesophageal reflux due to various factors. Gastroesophageal reflux is also easy to induce bronchial asthma. And after gastroesophageal reflux, asthma will aggravate, which is an important inducement of refractory asthma. The clinical treatment of gastroesophageal reflux patients should take the corresponding anti reflux treatment with the acid suppressant drugs, the effect is remarkable, it can significantly improve the lung function, the clinical promotion and extensive practice of the value.

Key words: Gastroesophageal reflux, Acid suppressant drugs, Bronchial asthma, Anti reflux therapy

Aizezi Kaisaier·, Rezike Gulibahaer·, Xiaohong Yang. Objective to investigate the relationship between gastroesophageal reflux and bronchial asthma, and analyze the effect of acid suppressant drug on gastroesophageal reflux (GER, Geriatrics)[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2019, 06(02): 70-74.

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References 16

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组别	例数	FEV1（L）	FEV1/FVC	MMEF（L）	PEF（L/S）
观察组	49	2.12±0.14	69.14±3.29	2.08±0.19	4.28±0.13
对照组	73	3.01±0.22	62.03±3.34	1.71±1.21	5.23±0.09
t值	?	3.7154	7.3641	3.2514	3.2841
P值	?	0.0002	0.0000	0.0281	0.0021

组别	例数	FEV1（L）	FEV1/FVC	MMEF（L）	PEF（L/S）
观察组	49	2.12±0.14	69.14±3.29	2.08±0.19	4.28±0.13
对照组	73	3.01±0.22	62.03±3.34	1.71±1.21	5.23±0.09
t值	?	3.7154	7.3641	3.2514	3.2841
P值	?	0.0002	0.0000	0.0281	0.0021

组别	例数	显效（例）	有效（例）	无效（例）	总有效率（%）
制酸治疗组	25	16	13	1	96.00
安慰剂治疗组	24	14	6	4	83.33^a

组别	例数	显效（例）	有效（例）	无效（例）	总有效率（%）
制酸治疗组	25	16	13	1	96.00
安慰剂治疗组	24	14	6	4	83.33^a

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