Gastroesophageal reflux disease (GERD) is one of the most common diseases of the digestive system. Its pathogenesis and clinical manifestations are complex and diverse, with a low clinical cure rate and a high recurrence rate, which seriously affect the quality of patients'health and increase family finances Burden and consumption of social medical resources are one of the more stubborn treatment problems in digestive system diseases. The treatment of GERD includes psychological and lifestyle intervention, standard medical treatment, endoscopy and surgical treatment if necessary, but drug treatment is still the first choice. Proton Pump Inhibitors (PPI) are currently the most widely used clinically effective class of strong acid inhibitors. This article reviews the research progress of PPI in GERD.