Chronic cough and gastroesophageal reflux disease: a bidirectional two-sample mendelian randomization study

doi:10.3877/cma.j.issn.2095-8765.2023.02.001

Abstract

Abstract:

Objective

Mendelian randomization was used to explore whether there is a causal relationship between gastroesophageal reflux disease (GERD) and chronic cough.

Methods

We extracted independent genetic variants strongly associated with chronic cough from two published genome-wide association studies (GWAS) and summary statistics for GERD from a GWAS analysis in the European Molecular Biology Laboratory. The causal relationship between chronic cough and GERD was assessed using inverse variance weighted (IVW) as main estimation.

Results

GERD was observed for causal association with increased risk for chronic cough for IVW analysis for applying two GWAS data (P=1.70×10⁻⁷ and P=2.42×10⁻⁵, respectively). However, there was no association of genetically predicted chronic cough with GERD (all P>0.05). None evidence of significant pleiotropy and heterogeneity was observed.

Conclusion

There was a causal relationship between GERD and increased risk of chronic cough.

Key words: Gastroesophageal reflux disease, Chronic cough, Mendelian randomization

Hongpeng Lu, Xin Yuan, Shuhao Zheng, Yi Liu, Lei Xu. Chronic cough and gastroesophageal reflux disease: a bidirectional two-sample mendelian randomization study[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(02): 59-64.

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Figures/Tables 3

References 15

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暴露	结局	MR	SNP数	OR (95%CI)	P 值
胃食管反流病	慢性咳嗽	IVW	88 ^a	1.03 (1.02~1.04)	1.70×10^-7
		MR Egger	88^a	0.99 (0.93~1.06)	0.87
		Weighted median	88^a	1.03 (1.02~1.05)	2.42×10^-5
		Weighted mode	88^a	1.04 (1.00~1.07)	0.06
		Simple mode	88^a	1.04 (1.00~1.08)	0.07
		IVW	86^b	1.28 (1.13~1.44)	8.88×10^-5
		MR Egger	86^b	0.62 (0.30~1.28)	0.20
		Weighted median	86^b	1.29 (1.07~1.54)	7.28×10^-3
		Weighted mode	86^b	1.35 (0.87~2.07)	0.18
		Simple mode	86^b	1.42 (0.90~2.22)	0.13
慢性咳嗽	胃食管反流病	IVW	7^a	1.76 (0.70~4.43)	0.23
		MR Egger	7^a	0.42 (0.01~13.34)	0.64
		Weighted median	7^a	1.13 (0.60~2.13)	0.75
		Weighted mode	7^a	1.11 (0.54~2.27)	0.78
		Simple mode	7^a	1.14 (0.55~2.36)	0.74
		IVW	2^b	1.03 (0.96~1.11)	0.45

暴露	结局	MR	SNP数	OR (95%CI)	P 值
胃食管反流病	慢性咳嗽	IVW	88 ^a	1.03 (1.02~1.04)	1.70×10^-7
		MR Egger	88^a	0.99 (0.93~1.06)	0.87
		Weighted median	88^a	1.03 (1.02~1.05)	2.42×10^-5
		Weighted mode	88^a	1.04 (1.00~1.07)	0.06
		Simple mode	88^a	1.04 (1.00~1.08)	0.07
		IVW	86^b	1.28 (1.13~1.44)	8.88×10^-5
		MR Egger	86^b	0.62 (0.30~1.28)	0.20
		Weighted median	86^b	1.29 (1.07~1.54)	7.28×10^-3
		Weighted mode	86^b	1.35 (0.87~2.07)	0.18
		Simple mode	86^b	1.42 (0.90~2.22)	0.13
慢性咳嗽	胃食管反流病	IVW	7^a	1.76 (0.70~4.43)	0.23
		MR Egger	7^a	0.42 (0.01~13.34)	0.64
		Weighted median	7^a	1.13 (0.60~2.13)	0.75
		Weighted mode	7^a	1.11 (0.54~2.27)	0.78
		Simple mode	7^a	1.14 (0.55~2.36)	0.74
		IVW	2^b	1.03 (0.96~1.11)	0.45

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