辣椒素受体与胃食管反流病发病机制的相关性研究

doi:10.3877/cma.j.issn.2095-8765.2023.03.010

中华胃食管反流病电子杂志 ›› 2023, Vol. 10 ›› Issue (03) : 156 -159. doi: 10.3877/cma.j.issn.2095-8765.2023.03.010

综述

辣椒素受体与胃食管反流病发病机制的相关性研究

苏拉依曼·牙库甫¹, 李义亮²^,^†(

), 克力木·阿不都热依木²

^1. 830001　乌鲁木齐，新疆维吾尔自治区人民医院微创、疝和腹壁外科
^2. 830001　乌鲁木齐，新疆维吾尔自治区人民医院微创、疝和腹壁外科;830001　乌鲁木齐，新疆维吾尔自治区人民医院自治区普外微创研究所

收稿日期:2023-02-21 出版日期:2023-08-15
通信作者: 李义亮

Study on the correlation between gastroesophageal reflux disease and the pathogenesis of capsaicin receptor

Yakufu Sulayiman·¹, Yiliang Li²^,^†(), Abudureyim Kelim·²

^1. Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China,
^2. Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China,;Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China

Received:2023-02-21 Published:2023-08-15
Corresponding author: Yiliang Li

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胃食管反流病（GERD）是一种常见的胃肠道运动障碍性疾病，其病因是胃内容物逆流直食管或口腔引起的。目前，此病在全球范围内发病率呈上升趋势。迄今为止，人们对胃食管反流的发病机制主要集中于反流机制方面深入探讨并研究。但近几年来，分子机制逐渐成为研究的热点。本综述旨重点探讨辣椒素受体对GERD发病机制进行叙述。

关键词: 胃食管反流病, 辣椒素受体, 胃调节, 胶质源性神经营养因子

Gastroesophageal reflux disease (GERD) is a common gastrointestinal motility disorder caused by the reflux of gastric contents into the straight esophagus or oral cavity. At present, the incidence rate of this disease is on the rise worldwide. So far, people's understanding of the pathogenesis of gastroesophageal reflux has mainly focused on in-depth exploration and research on the mechanism of reflux. But in recent years, molecular mechanisms have gradually become a research hotspot. This review focuses on the role of capsaicin receptor in the pathogenesis of GERD.

Key words: Gastroesophageal reflux diseas, Vanill oid receptor subtype 1, Gas accommodation, Glial-derived neurotrophic factor

图1 辣椒素受体受体结构示意图

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Study on the correlation between gastroesophageal reflux disease and the pathogenesis of capsaicin receptor