食管pH-阻抗监测通过记录食管腔内食团通过所引起的阻抗变化反应食团的性质及运动情况。弥补了食管pH监测、无线pH胶囊检测不能检测到弱酸、非酸反流的弱点，从而提高了检测反流事件的灵敏度，增加了反流检测的价值。食管pH-阻抗监测在某些情况下允许不停用抑酸药的情况下进行监测。传统的指标，如酸暴露时间、DeMeester评分在诊断胃食管反流病（GERD），特别是以酸反流为主的胃食管反流病中是主要指标。但食管pH-阻抗监测提高了反流症状关联、反流事件的检出率，提高了GERD的检出灵敏度。新的基于阻抗的指标如：反流后吞咽诱导蠕动波指数和食管基线阻抗提高了pH-阻抗监测在难治性胃食管反流病、功能性胃灼热、反流高敏感和GERD相关食管外症状等的临床诊断价值。本文描述了食管pH-阻抗监测在临床中应用，以期更好的利用食管pH-阻抗监测辅助诊断食管疾病。

Esophageal pH-resistance monitoring reflects the nature and movement of the bolus by recording the impedance changes caused by the passage of the bolus in the esophageal lumen. It compensates for the weak point of weak acid and non-acid reflux caused by esophageal pH monitoring and wireless pH capsule detection, which improves the sensitivity of detecting reflux events and increases the value of reflux detection. Esophageal pH-impedance monitoring can be monitored without deactivating proton pump inhibitors in some cases. Traditional indicators such as acid exposure time and DeMeester score are the main indicators in the diagnosis of gastroesophageal reflux disease (GERD), especially in gastroesophageal reflux disease with acid reflux. However, esophageal pH-impedance monitoring improves the detection rate of reflux-related symptoms and reflux events, and improves the detection sensitivity of GERD. New impedance-based indicators such as: postreflux swallow-induced peristaltic wave and esophageal baseline impedance improve pH-impedance monitoring in refractory gastroesophageal reflux disease, functional heartburn, reflux high sensitivity, and GERD-related extra-esophageal symptoms Clinical diagnostic value, This article describes the clinical application of esophageal pH-impedance monitoring in order to better use esophageal pH-impedance monitoring to assist in the diagnosis of esophageal diseases.