胃食管反流病与胸痛发生机制的相关性研究进展

doi:10.3877/cma.j.issn.2095-8765.2021.02.011

胃食管反流病（GERD）是指胃内容物反流引起反酸、烧心为主不良症状的一种疾病。胸痛作为GERD的重要并发症之一，分为心源性胸痛和非心源性胸痛，临床表现与心血管系统疾病极为相似，故临床上常被误诊为冠心病而延误病情，导致病情进一步加重或错失最佳治疗时机。为了提高对GERD所致的胸痛的认识，本文中笔者就GERD导致的胸痛的的最新研究进展进行汇总，旨在为该类胸痛未来的研究发展方向提出新思路。

关键词: 胃食管反流病, 胸痛, 发病机制

Gastroesophageal reflux disease (GERD) is a disease with adverse symptoms of acid reflux and heartburn caused by reflux of gastric contents. Chest pain, as one of the important complications of gastroesophageal reflux disease, is divided into cardiogenic chest pain and non-cardiogenic chest pain. Its clinical manifestation is very similar to cardiovascular system disease, so it is often misdiagnosed as "coronary heart disease" in clinic, which leads to further aggravation of the disease or loss of the best treatment window. In order to improve the understanding of chest pain caused by GERD, this paper comprehensively summarizes the latest progress of chest pain caused by gastroesophageal reflux disease, and puts forward new ideas for the future research and development of this kind of chest pain.

Key words: Gastroesophageal reflux disease, chest pain, pathogenesis

1	DS S, R F. Current Trends in the Management of Gastroesophageal Reflux Disease [J]. Gut and liver, 2018, 12(1): 7-16.
2	SD C, G G, K R, et al. Prevalence and factors associated with gastroesophageal reflux disease in southern India: A community-based study [J]. Indian journal of gastroenterology: official journal of the Indian Society of Gastroenterology, 2019, 38(1): 77-82.
3	SJ B, DN R, UC G, et al. Epidemiology and symptom profile of gastroesophageal reflux in the Indian population: report of the Indian Society of Gastroenterology Task Force [J]. Indian journal of gastroenterology: official journal of the Indian Society of Gastroenterology, 2011, 30(3): 118-127.
4	JDG C, PN T, R L. Lower prevalence of gastroesophageal reflux disease in patients with noncardiac chest pain on opiates: a cross-sectional study [J]. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus, 2018, 31(11): 11.
5	RD F, KM G, RW B. Mechanisms of cardiac pain [J]. Comprehensive Physiology, 2015, 5(2): 929-960.
6	S H, Y L, Y C, et al. Value of the Gastroesophageal Reflux Disease Questionnaire (GerdQ) in predicting the proton pump inhibitor response in coronary artery disease patients with gastroesophageal reflux-related chest pain [J]. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus, 2016, 29(4): 367-376.
7	T Y, R F. Noncardiac chest pain: diagnosis and management [J]. Current opinion in gastroenterology, 2017, 33(4): 293-300.
8	M M, G C, SH H, et al. Non-Cardiac Chest Pain: A Review of Environmental Exposure-Associated Comorbidities and Biomarkers [J]. EMJ Gastroenterology, 2018, 7(1): 103-112.
9	TVK H, AJ B, JM O, et al. Determinants of the Association between Non-Cardiac Chest Pain and Reflux [J]. The American journal of gastroenterology, 2017, 112(11): 1671-7.
10	A C, PA M, G T, et al. Cardioesophageal reflex: a mechanism for "linked angina" in patients with angiographically proven coronary artery disease [J]. Journal of the American College of Cardiology, 1996, 27(7): 1621-1628.
11	KA M, A S, BM R, et al. Non-cardiac chest pain: prognosis and secondary healthcare utilisation [J]. Open heart, 2018, 5(2): e000859.
12	T T, MJ P, F P. A Modern Approach to the Surgical Treatment of Gastroesophageal Reflux Disease [J]. Journal of laparoendoscopic & advanced surgical techniques Part A, 2016, 26(3): 174-179.
13	N G, J A, M-RC , et al. Review article: the current treatment of non-cardiac chest pain [J]. Alimentary pharmacology & therapeutics, 2016, 43(2): 213-239.
14	Sakamoto JT, Nan L, Zhi XK, et al. Heart Rate Variability Analysis in Patients Who Have Bradycardia Presenting to the Emergency Department with Chest Pain [J]. The Journal of emergency medicine, 2018, 54(3): 273-280.
15	K M, T T, K A, et al. Real-time 3-dimensional imaging of the esophagus and left atrium with a noncontact mapping system [J]. Circulation journal: official journal of the Japanese Circulation Society, 2009, 73(5): 826-832.
16	TC H, LW L, S Y, et al. Gastroesophageal reflux disease and atrial fibrillation: Insight from autonomic cardiogastric neural interaction [J]. Journal of cardiovascular electrophysiology, 2019, 30(11): 2262-2270.
17	M S, SJ R, D C, et al. Atrial fibrillation symptom clusters and associated clinical characteristics and outcomes: A cross-sectional secondary data analysis [J]. European journal of cardiovascular nursing: journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology, 2018, 17(8): 707-716.
18	D L, C U, F M, et al. Atrial autonomic innervation: a target for interventional antiarrhythmic therapy? [J]. Journal of the American College of Cardiology, 2014, 63(3): 215-224.
19	H T, C O, T U. History of gastroesophageal reflux disease in patients with suspected coronary artery disease [J]. Heart and vessels, 2019, 34(10): 1631-1638.
20	U S, S V, P K, et al. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal [J]. Physiological reviews, 2011, 91(1): 265-325.
21	AJ B, BL W, WL C, et al. Determinants of perception of heartburn and regurgitation [J]. Gut, 2006, 55(3): 313-318.
22	AJ M, JS D C, AJ C, et al. Sensitization to painful distention and abnormal sensory perception in the esophagus [J]. Gastroenterology, 1995, 108(2): 311-319.
23	VM K, GS S, CP G. Abnormal GERD parameters on ambulatory pH monitoring predict therapeutic success in noncardiac chest pain [J]. The American journal of gastroenterology, 2010, 105(5): 1032-1038.
24	SK R, MD C, JK D, et al. Opioid-Induced Esophageal Dysfunction (OIED) in Patients on Chronic Opioids [J]. The American journal of gastroenterology, 2015, 110(7): 979-984.
25	A J, HP P. Chronic opioids in gastroparesis: Relationship with gastrointestinal symptoms, healthcare utilization and employment [J]. World journal of gastroenterology, 2017, 23(40): 7310-7320.

[1]	林凌, 李佩, 赵玮. 牛牙样牙发病机制的研究进展[J]. 中华口腔医学研究杂志(电子版), 2023, 17(02): 75-80.
[2]	贾卓奇, 周维茹, 张勇, 张广健, 付军科. 达·芬奇机器人与腹腔镜食管裂孔疝修补术的对比研究[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(04): 410-414.
[3]	唐凯, 刘正峰, 宋佳蔚, 卢秀珍. 角膜巩膜干凹斑的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 231-235.
[4]	李文捷, 卢弘. 幼年特发性关节炎相关葡萄膜炎的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(01): 40-44.
[5]	张坤淇, 张睿, 徐佳, 康庆林. 漂浮膝损伤的诊治进展[J]. 中华老年骨科与康复电子杂志, 2023, 09(04): 252-256.
[6]	金刚, 李英真, 施维, 李博. 帕金森病在病理生理学中的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 315-319.
[7]	王敏, 张妍, 王盈熹, 赵龙, 夏书月. 外泌体在慢性阻塞性肺疾病中的作用[J]. 中华临床实验室管理电子杂志, 2023, 11(01): 45-51.
[8]	王擎, 王冠峰, 陈星. 胃食管阀瓣的Hill分级在胃食管反流病中的应用价值[J]. 中华胃肠内镜电子杂志, 2023, 10(02): 125-130.
[9]	张继舜, 陈思旭, 钱洁, 尚占民, 郝建宇. 平均夜间基线阻抗对食管外症状胃食管反流病的临床诊断价值[J]. 中华胃肠内镜电子杂志, 2023, 10(02): 97-102.
[10]	陆洪鹏, 袁芯, 郑树灏, 刘怡, 徐磊. 慢性咳嗽与胃食管反流病：双向两样本孟德尔随机化研究[J]. 中华胃食管反流病电子杂志, 2023, 10(02): 59-64.
[11]	范勇, 张利昉, 杨美琳. 改良经口内镜下贲门缩窄术治疗胃食管反流病效果分析[J]. 中华胃食管反流病电子杂志, 2023, 10(02): 65-68.
[12]	文明, 熊英, 艾克拜尔·艾力, 克力木·阿不都热依木. 质子泵抑制剂治疗期间焦虑对胃食管反流病疗效的影响[J]. 中华胃食管反流病电子杂志, 2023, 10(02): 90-95.
[13]	李鹏, 刘国祥, 李汝红. 经口内镜下贲门缩窄术治疗胃食管反流病的研究进展[J]. 中华胃食管反流病电子杂志, 2023, 10(02): 96-99.
[14]	买买提·依斯热依力, 尹强, 尹海龙, 董雨微, 王永康, 克力木·阿不都热依木, 阿吉艾克拜尔·艾萨. 传统医药治疗胃食管反流病的研究进展[J]. 中华胃食管反流病电子杂志, 2023, 10(02): 100-104.
[15]	张高松, 杨美琳, 袁莉, 俞炎波, 石琳妮. 内镜下贲门缩窄术对改善胃食管反流病患者生活质量的观察[J]. 中华胃食管反流病电子杂志, 2023, 10(01): 18-21.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Research progress on the relationship between gastroesophageal reflux disease and chest pain

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Research progress on the relationship between gastroesophageal reflux disease and chest pain