腹腔镜袖状胃切除术（LSG）对胃食管反流病（GERD）患病率的影响尚不清楚。我们的目的是分析LSG对GERD的影响。

制定检索策略，对万方、知网、PubMed、EMbase、The Cochrane Library及Web of Science数据库进行检索，按照纳入标准和排除标准筛选文献，提取纳入文献的相关数据，并对其进行方法学质量评价和Meta分析统计方法来验证。

共纳入11篇文献、1034例患者。Meta分析结果显示，LSG手术后新出现GERD症状的比较差异具有统计学意义（OR=0.39，95% CI：0.26~0.60，P<0.0001），LSG术后新出现的GERD症状较术前明显增多；此外，LSG手术前后GERD-Q评分比较差异具有统计学意义（MD=-0.59，95% CI：-1.07~-0.11，P=0.02<0.05），从森林图可以看出代表合并后效应量的菱形坐落于左侧，提示LSG术后GERD症状明显加重；LSG手术前后24 h pH检测中DeMeester score比较差异具有统计学意义（MD=-11.82，95% CI：-16.27~-7.37，P<0.000 01），从森林图可以看出代表合并后效应量的菱形坐落于左侧，提示LSG术后GERD症状较术前明显加重；LSG手术前后酸反流平均次数比较差异具有统计学意义（MD=-15.71，95% CI：-23.97~-7.44，P=0.0002<0.05），从森林图可以看出代表合并后效应量的菱形坐落于左侧，提示LSG术后酸反流平均次数较术前明显增多；LSG手术前后24 h pH检测中酸反流时间比较差异具有统计学意义（SMD=-1.00，95% CI：-1.38~-0.61，P<0.000 01），从森林图可以看出代表合并后效应量的菱形坐落于左侧，提示LSG术后酸反流时间较术前明显延长；LSG手术前后每日质子泵抑制剂（proton pump inhibitor, PPI）摄入量比较差异具有统计学意（RR=0.41，95% CI：0.23~0.73，P=0.002<0.05），从森林图可以看出代表合并后效应量的菱形坐落于左侧，提示LSG术后每日PPI摄入量较术前明显增多。但是，LSG手术前后GERD症状的变化比较差异具无统计学意义（OR=0.97，95% CI：0.46~2.04，P=0.093>0.05），LSG手术前后GERD症状无明显变化。

由于现有研究测试结果的矛盾性，LSG对GERD患病率的确切影响仍未得到回答。外科医生在选择合适的减肥技术时，应仔细评估术前的GERD症状,以更清楚地确定SG对减肥患者GERD的影响。

The effect of laparoscopic sleeve gastrectomy (LSG) on the prevalence of gastroesophageal reflux disease (GERD) is unclear. Our aim is to analyze the impact of LSG on GERD.

Make the retrieval strategy, search the Wanfang, Zhiwang, PubMed, EMbase, The Cochrane Library and Web of Science databases, screen the literature according to the inclusion criteria and exclusion criteria, extract the relevant data of the included literature, and carry on the methodological quality evaluation and Meta analysis.

A total of 11 articles and 1034 patients were included. The results of Meta analysis showed that the difference of new GERD symptoms after LSG operation was statistically significant (OR=0.39,95% CI:0.26~0.60), LSG P<0.0001). The number of new GERD symptoms after operation was significantly higher than that before operation. In addition, there was significant difference in GERD-Q score before and after LSG (MD=-0.59, 95% CI:-1.07~-0.11). The rhombus representing the combined effect was located on the left side from the forest map, indicating that the symptoms of GERD were significantly aggravated after LSG. There was significant difference in DeMeester score in 24-hr pH before and after LSG (MD=-11.82,95% CI:-16.27~-7.37, P<0.000 01). From the forest map, we can see that the diamond representing the combined effect is located on the left, suggesting that the symptoms of GERD after LSG are significantly more severe than before. There was a significant difference in the average number of acid reflux before and after LSG (MD=-15.71,95% CI:-23.97~-7.44). From the forest map, we can see that the diamond representing the combined effect is located on the left, suggesting that the average number of acid reflux after LSG is significantly higher than that before operation. The time of acid reflux detected by 24-hr pH before and after LSG was significantly different (SMD=-1.00,95% CI:-1.38~-0.61 P<0.000 01). From the forest map, we can see that the diamond representing the combined effect is located on the left, suggesting that the acid reflux time after LSG is significantly longer than that before operation. The difference of daily PPI intake before and after LSG was statistically significant (RR=0.41,95% CI:0.23~0.73). From the forest map, we can see that the diamond representing the combined effect is located on the left, suggesting that the daily PPI intake after LSG is significantly higher than that before operation. However, there was no significant difference in the changes of GERD symptoms before and after LSG operation (OR=0.97,95% CI:0.46~2.04), LSG 0.093>0.05). There was no significant change in GERD symptoms before and after), LSG operation.

Due to the contradictory results of existing studies, the exact effect of LSG on the prevalence of GERD has not been answered. When choosing the appropriate weight loss technique, surgeons should carefully evaluate the preoperative symptoms of GERD in order to more clearly determine the effect of SG on GERD in patients with weight loss.