胃食管反流病相关非心源性胸痛患者食道患病率调查研究

doi:10.3877/cma.j.issn.2095-8765.2020.02.005

中华胃食管反流病电子杂志 ›› 2020, Vol. 07 ›› Issue (02) : 93 -97. doi: 10.3877/cma.j.issn.2095-8765.2020.02.005

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论著

胃食管反流病相关非心源性胸痛患者食道患病率调查研究

阿不来克木·马合木提¹, 买买提·依斯热依力², 阿里木·买买提¹, 张雷¹, 克力木·阿不都热依木²^,^†(

)

^1. 830001　乌鲁木齐，新疆维吾尔自治区人民医院急诊创伤外科
^2. 830001　乌鲁木齐，新疆维吾尔自治区人民医院微创、疝和腹壁外科；830001　乌鲁木齐，新疆维吾尔自治区人民医院普外微创研究所

收稿日期:2019-04-30 出版日期:2020-05-15
通信作者: 克力木·阿不都热依木
基金资助:
新疆维吾尔自治区自然科学基金项目(2018D01C134)

Investigation of esophageal morbidity in patients with non cardiac chest pain

Abulaikemu·Mahamuti¹, Maimaiti·Yisireyili², Alimu·Maimaiti¹, Lei Zhang¹, Kelimu·Abudureyimu²^,^†()

^1. Derartment of Emergency and Traumatic Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
^2. Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China; Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China

Received:2019-04-30 Published:2020-05-15
Corresponding author: Kelimu·Abudureyimu
About author:
Corresponding author: Kelimu·Abudureyimu, Email: klm6075@163.com
Abulaikemu·Mahamuti Lei,Maimaiti·Yisireyili Lei,Alimu· Maimaiti Lei,et al.Investigation of esophageal morbidity in patients with non cardiac chest pain[J].Chin J Gastroesophagol Reflux Dis (Electronic Edition),2020,07(02):93-97.

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阿不来克木·马合木提, 买买提·依斯热依力, 阿里木·买买提, 张雷, 克力木·阿不都热依木. 胃食管反流病相关非心源性胸痛患者食道患病率调查研究[J]. 中华胃食管反流病电子杂志, 2020, 07(02): 93-97.

Abulaikemu·Mahamuti, Maimaiti·Yisireyili, Alimu·Maimaiti, Lei Zhang, Kelimu·Abudureyimu. Investigation of esophageal morbidity in patients with non cardiac chest pain[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2020, 07(02): 93-97.

目的

探讨非心源性胸痛（NCCP）患者中食道患病率情况及其临床特点。

方法

选取2018年1月至2019年4月在新疆维吾尔自治区人民医院因NCCP就诊的85例患者为研究对象。其中，男性45例（52.94%），平均年龄为41.2±12.4；女性为40例（47.06%），平均年龄为43.3±10.9。对所有的研究对象进行上消化道内镜检查、高分辨率食道测压和24 h动态食管pH监测。均值、标准差（SD）、范围、频率、百分比（如果连续和正态分布）和比例（如果分类）进行描述性统计；符合正态分布的计量资料均以（

x ˉ ± s

）表示，比较采用t检验。

结果

NCCP患者中最常见的症状为酸反流43.53%，吞咽困难31.76%，烧心24.71%。上消化道内镜检查异常者占31.76%，高分辨率食管测压异常者占67.06%，动态pH监测异常者占34.76%。上消化道内镜检查联合24 h pH监测确定胃食管反流病（GERD）的患病率为42.36%。基于食管测压检查23.53%的NCCP患者无效食管动力是NCCP最常见的病因。

结论

通过分析食管源性引起NCCP的病因，有助于临床医生排除其它导致胸痛的高危因素，并为其诊疗提供适当的治疗方案。

关键词: 非心源性胸痛, 胃食管反流病, 食道运动功能障碍

Objective

To investigate the prevalence and clinical characteristics of esophagus in patients with non-cardiac chest pain (NCCP).

Methods

Patients who diagnosed with NCCP from January 2018 to April 2019 in Xinjiang Uygur Autonomous Region People's Hospital were selected as the study subjects. Detailed medical history, physical examination, upper gastrointestinal endoscopy, high resolution esophageal manometry and 24 h dynamic esophageal pH monitoring were performed on all subjects.

Results

The total number of subjects was 85, of which male 45(52.94%), with an average age of 41.2±12.4 years;female was 40 (47.06%), with an average age of 43.3±10.9 years. The most common symptoms in NCCP patients were acid reflux 43.53%, dysphagia 31.76%, heartburn 24.71%. Endoscopic abnormalities of upper gastrointestinal tract accounted for 31.76%, esophageal manometry abnormalities accounted for 67.06%, and dynamic pH monitoring abnormalities accounted for 34.76%. The prevalence of GERD was 42.36% determined by upper gastrointestinal endoscopy combined with 24 h pH monitoring. According to manometric results, ineffective esophageal motility in 23.53% of NCCP patients was the most common cause of NCCP.

Conclusion

By analyzing the causes of esophagogenous NCCP, it is helpful for clinicians to exclude other high-risk factors leading to chest pain and to provide appropriate treatment for their diagnosis and treatment

Key words: Non-cardiogenic chest pain, Gastroesophageal reflux disease, Esophageal motor dysfunction

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Investigation of esophageal morbidity in patients with non cardiac chest pain

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Investigation of esophageal morbidity in patients with non cardiac chest pain