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中华胃食管反流病电子杂志 ›› 2020, Vol. 07 ›› Issue (04) : 228 -235. doi: 10.3877/cma.j.issn.2095-8765.2020.04.008

综述

胃食管反流病大鼠模型探讨
陈小苏1, 王艳1, 鲍云1, 王艳娟1, 林琳1, 叶必星1,()   
  1. 1. 210029 南京医科大学第一附属医院消化科
  • 收稿日期:2020-03-19 出版日期:2020-11-05
  • 通信作者: 叶必星

Exploring the Rat models of Gastroesophageal Reflux Disease

Xiaosu Chen1, Yan Wang1, Yun Bao1, Yanjuan Wang1, Lin Lin1, Bixing Ye1,()   

  1. 1. Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,China
  • Received:2020-03-19 Published:2020-11-05
  • Corresponding author: Bixing Ye
引用本文:

陈小苏, 王艳, 鲍云, 王艳娟, 林琳, 叶必星. 胃食管反流病大鼠模型探讨[J/OL]. 中华胃食管反流病电子杂志, 2020, 07(04): 228-235.

Xiaosu Chen, Yan Wang, Yun Bao, Yanjuan Wang, Lin Lin, Bixing Ye. Exploring the Rat models of Gastroesophageal Reflux Disease[J/OL]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2020, 07(04): 228-235.

胃食管反流病GERD为消化科常见病之一,其发病机制复杂。大鼠模型可用来研究GERD的发病机制并为新的临床治疗方式带来希望。目前国内外有两类方法构建GERD大鼠模型,一类是外源性食管灌注化学物质诱发,另一类是手术干预改变大鼠胃肠道生理结构来实现。本综述主要从急性GERD大鼠模型和慢性GERD大鼠模型两大方面探讨。

GERD is one of the most common diseases in the department of gastroenterology, and its pathogenesis is complex. The rat model can be used to study the pathogenesis of GERD to bring hope for the new clinical treatment. At present, there are two kinds of methods to establish GERD rat model. One is induced by exogenous esophageal perfusion of chemicals. The other is to change the physiological structure of the gastrointestinal tract by surgical intervention. The review focuses on two aspects, 1) acute GERD rat model. 2) chronic GERD rat model.

图1 完全幽门结扎术
图2 外源性食管灌注微渗透泵模式图
图3 部分幽门结扎+前胃结扎术
图4 食管-胃成形术
图5 食管-幽门前吻合术
图6 贲门成形+幽门结扎+胃Roux-en-Y式吻合术
图7 食管-空肠吻合+全胃切除术
图8 食管-十二指肠吻合+全胃切除术
图9 食管-十二指肠侧侧吻合术
图10 食管-十二指肠侧侧吻合+贲门结扎术
图11 食管-胃-十二指肠吻合术
图12 食管-十二指肠端侧吻合+保留全胃术
图13 食管-胃-空肠吻合术
图14 食管-空肠吻合+保留全胃术
图15 Roux-en-Y 式食管-空肠吻合+保留全胃术
图16 食管空肠吻合+胃空肠吻合术
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