目的

初步探讨抗反流黏膜消融术（ARMA）治疗反流高敏感（RH）的疗效。

方法

回顾分析2022年8月至2023年8月于火箭军特色医学中心胃食管外科接受内镜下ARMA治疗的8例RH患者的疗效，比较治疗前后胃食管反流相关症状的主观缓解程度、抑酸药停药率、术后并发症、复发和再次治疗情况。

结果

本组RH患者男性3例，女性5例，平均年龄53岁。ARMA术后平均随访时间18个月，术后患者的反酸、烧心和胸/背痛症状的主观缓解度分别为72%（38，10）%、70%（50，95）%和70%（25，97）%，且症状评分较术前均有显著下降（P＜0.05）。术后抑酸药停药率为87.5%（7/8），疗效满意率为75%（6/8）。术后吞咽疼痛不适2例、腹胀和上腹痛各有1例，均为轻度，均保守治疗1周内缓解，无术后吞咽困难病例。症状部分复发1例，无再次抗反流干预病例。

结论

ARMA可减轻大部分RH患者的GERD症状，有较高的疗效满意率和抑酸药停药率。术后并发症较少且轻微。然而ARMA更准确的安全性和疗效需进一步研究。

Objective

To investigate the efficacy of anti-reflux mucosal ablation （ARMA） in treating reflux hypersensitivity （RH）.

Method

A retrospective analysis was conducted on the efficacy of 8 RH patients who received endoscopic ARMA treatment at Department of Gastroesophageal Surgery Department of Rocket Force Characteristic Medical Center from August 2022 to August 2023. The subjective relief of gastroesophageal reflux related symptoms， discontinuation rate of acid suppressant， postoperative complications， recurrence， and re treatment were compared before and after ARMA.

Results

There were 3 males and 5 females in this group of RH patients， with a mean of 53 years. The mean follow-up time after ARMA was 18 months， and the subjective relief rates of acid reflux， heartburn， and chest/back pain symptoms in postoperative patients were 72%（38， 10）%， 70%（50， 95）%， and 70%（25， 97）%， respectively. And the symptom scores were significantly lower than before surgery （all P＜0.05）. The postoperative discontinuation rate of acid suppressing drug was 87.5% （7/8）， and the satisfaction rate of therapeutic effect was 75% （6/8）.There were 2 cases of postoperative swallowing pain discomfort， 1 case of abdominal distension， and 1 case of upper abdominal pain， all of which were mild and relieved within 1 week after conservative treatment.There were no cases of postoperative dysphagia. There was 1 case of partial recurrence of symptoms and no cases of anti-reflux reintervention.

Conclusion

ARMA can alleviate the GERD symptoms in most RH patients， with a high satisfaction rate of efficacy and acid suppressing drug discontinuation rate. Postoperative complications are rare and mild. However， further research is needed to determine the more accurate safety and efficacy of ARMA.