Analysis of gastric acid reflux and GERD symptoms in perimenopausal women

doi:10.3877/cma.j.issn.2095-8765.2022.03.003

Abstract

Abstract:

Objective

To investigate characterictics of acid reflux and symptoms in perimenopausal women.

Methods

A retrospective study was made on 93 gastroesophageal reflux diseases (GERD) patients who were diagnosed in the people's Hospital of Xinjiang Uygur Autonomous Region from March 2017 to June 2018. Those patients were divided into perimenopausal group (43 cases) and non perimenopausal group (50 cases) basing on their menstrual conditions. GERD questionnaire survey, 24 h esophageal pH monitoring and high-resolution esophageal motility monitoring were used to analyze GERD related symptoms, acid reflux, and characteristics gastroesophageal motility.

Results

The average age range of perimenopausal women was higher than that of non menopausal women (P＜0.05); The typical symptoms of GERD such as heartburn and acid regurgitation in perimenopausal women were higher than that in non menopausal women (P＜0.05);Atypical symptom of belching and sleeping disorders in perimenopausal women was higher than that in non menopausal women (P＜0.05); 24-hour esophageal acid reflux test score showed that the number of weak acid reflux (4＜pH＜7) and percentage of weak acid reflux (%) in the perimenopause group were significantly higher than those in the non perimenopause group (P＜0.05); The resting pressure of the lower esophageal sphincter (LES) in the perimenopause group was lower than that non perimenopause group (P＜0.05), and the resting pressure of the upper esophageal sphincter (UES) was higher than perimenopause group (P＜0.05) .

Conclusion

The weak acid reflux and LES, UES function alternation is main phenmamonon in perimenopause women, and main atypical symptoms are belching and sleep disorders.

Key words: Gastroesophageal reflux, Perimenopausal women, Symptoms, Acid reflux, Esophageal motility

Aziguli·Alimujiang, Maimaiti·Yisireyili, Jing Wang, Ababokeli Wusiman, Meihua Chen, Ping Lu, Kelimu·Abudureyimu. Analysis of gastric acid reflux and GERD symptoms in perimenopausal women[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2022, 09(03): 151-155.

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References 20

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组别	例数	年龄（岁）	体质量指数（kg/m²）	病程（个月）
非围绝经期组	50	47.56±9.78	25.30±2.74	9.74±2.15
围绝经期组	43	34.20±6.37	26.21±2.37	10.30±2.07
t值		7.657	-1.695	-1.276
P值		＜0.001	0.094	0.205

组别	例数	年龄（岁）	体质量指数（kg/m²）	病程（个月）
非围绝经期组	50	47.56±9.78	25.30±2.74	9.74±2.15
围绝经期组	43	34.20±6.37	26.21±2.37	10.30±2.07
t值		7.657	-1.695	-1.276
P值		＜0.001	0.094	0.205

组别	例数	典型症状				非典型症状
组别	例数	烧心	反酸	胸骨后疼痛	反食	嗳气	吞咽困难	咽喉炎	咳嗽	哮喘	睡眠障碍	无症状
非围绝经期组	50	5（10.00）	4（8.00）	3（6.98）	2（8.00）	3（6.00）	2（4.00）	3（6.00）	1（2.00）	1（2.00）	2（4.00）	20（40.00）
围绝经期组	43	12（27.90）	11（25.58）	4（9.30）	4（9.30）	10（23.25）	3（4.65）	1（2.33）	2（4.65）	3（6.98）	9（20.93）	3（6.98）
χ²值		4.963	4.063	0.043	0.378	4.38	0.03	0.128	0.018	0.445	4.834	11.828
P值		0.026	0.044	0.835	0.539	0.036	0.862	0.720	0.894	0.505	0.028	0.001

组别	例数	典型症状				非典型症状
组别	例数	烧心	反酸	胸骨后疼痛	反食	嗳气	吞咽困难	咽喉炎	咳嗽	哮喘	睡眠障碍	无症状
非围绝经期组	50	5（10.00）	4（8.00）	3（6.98）	2（8.00）	3（6.00）	2（4.00）	3（6.00）	1（2.00）	1（2.00）	2（4.00）	20（40.00）
围绝经期组	43	12（27.90）	11（25.58）	4（9.30）	4（9.30）	10（23.25）	3（4.65）	1（2.33）	2（4.65）	3（6.98）	9（20.93）	3（6.98）
χ²值		4.963	4.063	0.043	0.378	4.38	0.03	0.128	0.018	0.445	4.834	11.828
P值		0.026	0.044	0.835	0.539	0.036	0.862	0.720	0.894	0.505	0.028	0.001

组别	例数	弱酸反流次数（4＜pH＜7，次）	酸反流次数（pH≤4，次）	所有反流总次数（次）	立位酸反流次数（次）	卧位酸反流次数（次）	餐后酸反流次数（次）	食管近端弱酸反流（%）	食管近端酸反流（%）	DeMeester评分（分）
非围绝经期组	50	18.82±3.84	17.44±2.90	29.74±4.48	17.06±4.40	10.78±2.51	2.86±1.08	26.34±5.76	32.53±5.13	17.68±6.20
围绝经期组	43	33.40±5.20	18.02±1.76	31.23±3.15	18.53±2.83	10.51±2.16	3.04±0.87	41.62±5.98	33.37±6.16	20.04±5.91
t值		-15.494	-1.148	-1.829	-1.885	0.547	-0.902	-12.522	-0.714	-1.873
P值		＜0.001	0.254	0.071	0.063	0.586	0.369	＜0.001	0.477	0.064

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