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中华胃食管反流病电子杂志 ›› 2018, Vol. 05 ›› Issue (04) : 179 -182. doi: 10.3877/cma.j.issn.2095-8765.2018.04.010

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综述

酸敏感受体与心理因素在胃食管反流病内脏高敏感产生的作用研究
吾布力卡斯木·吾拉木1, 买买提·依斯热依力2, 克力木·阿不都热依木2,()   
  1. 1. 830001 乌鲁木齐,新疆维吾尔自治区人民医院普外微创研究所;830054 乌鲁木齐,新疆医科大学研究生学院
    2. 830001 乌鲁木齐,新疆维吾尔自治区人民医院普外微创研究所,830001 乌鲁木齐,新疆维吾尔自治区人民医院微创、疝和腹壁外科
  • 收稿日期:2018-08-08 出版日期:2018-11-15
  • 通信作者: 克力木·阿不都热依木

Effects of acid sensitive receptors and psychological factors in the mechanism of visceral hypersensitivity in gastroesophageal reflux disease

Wulamu Wubulikasimu·1, Yisireyili Maimaiti·2, Abudureyimu Kelimu·2,()   

  1. 1. Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China;Graduate School of Xinjiang Medical University, Xinjiang Medical University, Urumqi, 830054, China
    2. Research Institute of General and Minimally Invasive Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China;Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China
  • Received:2018-08-08 Published:2018-11-15
  • Corresponding author: Abudureyimu Kelimu·
  • About author:
    Corresponding author: Kelimu·Abudureyimu, Email:
引用本文:

吾布力卡斯木·吾拉木, 买买提·依斯热依力, 克力木·阿不都热依木. 酸敏感受体与心理因素在胃食管反流病内脏高敏感产生的作用研究[J/OL]. 中华胃食管反流病电子杂志, 2018, 05(04): 179-182.

Wulamu Wubulikasimu·, Yisireyili Maimaiti·, Abudureyimu Kelimu·. Effects of acid sensitive receptors and psychological factors in the mechanism of visceral hypersensitivity in gastroesophageal reflux disease[J/OL]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2018, 05(04): 179-182.

胃食管反流病(GERD)是一类常见的消化道良性疾病,通常以烧心和反酸为典型症状出现。临床上以质子泵抑制剂做为首选药物控制GERD患者的症状,但部分患者治疗效果并不理想。目前认为,食管内脏高敏感(VH)是GERD关键的发病机制之一,成为了近年来的研究热点。VH表现为低阈值刺激即可引起的相对强烈的反应或不适,本文从酸敏感受体和心理因素的角度对GERD内脏高敏感产生中的作用做一综述。

Gastroesophageal reflux disease (GERD) is a common gastrointestinal benign disease, which can be characterized by typical symptoms such as heartburn and regurgitation. Clinically, symptoms of GERD patients can be controlled by proton pump inhibitors (PPIs) , but the consequence after the treatment is unsatisfactory in some patients. According to recent studies, visceral hypersensitivity (VH), which caused by low threshold stimulus and results in strong reaction or discomfort, plays a key role in the pathogenesis of GERD. Here we briefly reviewed the effects of acid sensitive receptors and psychological factors in the mechanism of visceral hypersensitivity in GERD.

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