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中华胃食管反流病电子杂志 ›› 2019, Vol. 06 ›› Issue (03) : 156 -160. doi: 10.3877/cma.j.issn.2095-8765.2019.03.010

所属专题: 文献

综述

食管裂孔疝潜在风险因素之胶原蛋白代谢的研究进展
帕尔哈提江·阿布力米提1, 克力木·阿不都热依木2,()   
  1. 1. 830011 乌鲁木齐,新疆医科大学研究生院
    2. 830011 乌鲁木齐,新疆医科大学研究生院;830001 乌鲁木齐,新疆维吾尔自治区人民医院微创、疝和腹壁外科
  • 收稿日期:2019-01-05 出版日期:2019-08-15
  • 通信作者: 克力木·阿不都热依木

Advances in Research on Collagen Metabolism of Potential Risk Factors for Hiatal Hernia

Paerhatijiang·Abulimiti1, Kelimu·Abudoureyimu2,()   

  1. 1. Xinjiang Medical University, Urmuqi 830011, China
    2. Xinjiang Medical University, Urmuqi 830011, China; Department of Minimally Invasive Surgery & Hernia and Abdominal Wall Surgery, Xinjiang People's Hospital, Urmuqi 830001, China
  • Received:2019-01-05 Published:2019-08-15
  • Corresponding author: Kelimu·Abudoureyimu
  • About author:
    Corresponding author: Kelim·Abudoureyimu, Email:
引用本文:

帕尔哈提江·阿布力米提, 克力木·阿不都热依木. 食管裂孔疝潜在风险因素之胶原蛋白代谢的研究进展[J]. 中华胃食管反流病电子杂志, 2019, 06(03): 156-160.

Paerhatijiang·Abulimiti, Kelimu·Abudoureyimu. Advances in Research on Collagen Metabolism of Potential Risk Factors for Hiatal Hernia[J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2019, 06(03): 156-160.

食管裂孔疝(HH)是临床上常见的消化系统疾病之一,由于临床症状缺乏特异性、发病率及术后复发率较高,严重影响患者的生活质量。食管裂孔疝的发病机制尚未明确,腹腔压力增高被认为主要原因之一,研究发现在患者胃食管连接部周围组织存在明显的胶原蛋白代谢紊乱,而且参与其中的胶原蛋白是HH发生的主要风险因素。这种紊乱可导致组织结构的薄弱和强度的降低,并在腹腔压力增高的基础上促进食管裂孔疝的形成以及复发。胶原蛋白代谢相关的生化因素均可成为HH发生的潜在风险因素。本文旨在综述国内外HH及胶原蛋白代谢相关的潜在风险因素,为进一步深究HH的发病机制奠定理论基础。

Hiatal hernia (HH) is one of the most common digestive diseases in the clinic. Due to the lack of specificity of clinical symptoms with the high incidence and recurrence rate, HH seriously affects the quality of the patients’ life.The pathogenesis of HH is not clear, and the increase of abdominal pressure is considered to be one of the main reasons. The study found that there is obvious collagen metabolism disorder in the tissues around the patient's gastroesophageal junction, and the collagen involved is the main risk factor for HH. This disorder can lead to weak tissue structure and reduced strength, and promote the formation and recurrence of HH based on increased abdominal pressure. Biochemical factors associated with collagen metabolism can be a potential risk factor for HH. This article aims to summarize the potential risk factors of HH and collagen metabolism at home and abroad, and lay a theoretical foundation for further study on the pathogenesis of HH.

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