探讨近端食管异位胃粘膜黏膜与胃食管反流关系。

选取2021年7月至2021年12月于中山大学附属第七医院（深圳）收治的成人胃镜检查资料，根据有无近端食管异位胃黏膜分为观察组和对照组，随机选取纳入病例，运用t检验或χ²对年龄、性别、是否具有胃食管反流病或胃食管反流的解剖学基础3个因素进行统计学分析。

观察组和对照组各纳入患者215例，观察组年龄（43.4±10.7）岁，对照组年龄（42.8±11.7）岁，差异无统计学意义（P=0.211）；2组之间性别组成差异无统计学意义（P=0.845）；观察组49.8%（107/215）存在胃食管反流病或胃食管反流解剖学基础，而对照组39.5%（85/215）存在胃食管反流病或胃食管反流解剖学基础，差异有统计学意义（P=0.042）。

近端食管异位胃黏膜可能为胃食管反流物的作用下化生的结果，近端食管异位胃黏膜提示存近端食管反流的可能。

Selected the data of adult gastroscopy in our hospital from July 1, 2021 to December 31, 2021, the patients were divided into observation group and control group according to the presence or absence of proximal ectopic gastric mucosa, Statistical analysis was conducted according to age, gender, presence of gastroesophageal reflux disease and anatomical basis of gastroesophageal reflux, and P＜0.05 was considered statistically significant.

A total of 215 patients were included in the observation group and the control group, with an average age of (43.4±10.7) years in the observation group and (42.8±11.7) years in the control group, and there was no significant difference in age between the two groups (P=0.211). There was no significant difference in gender composition between the two groups (P=0.845). In the observation group, 49.8% (107/215) had the gastroesophageal reflux disease or the anatomical basis of gastroesophageal, while 39.5% (85/215) of the control group had the gastroesophageal reflux disease or the anatomical basis of gastroesophageal, the difference was statistically significant (P=0.042).

Proximal esophageal ectopic gastric mucosa may be the result of metaplasia under the impact of gastroesophageal reflux, proximal esophageal ectopic gastric mucosa suggests the possibility of proximal esophageal reflux.

To study the relationship between ectopic gastric mucosa of proximal esophagus and gastroesophageal reflux.